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ENZYME

ENZYME entry: EC 2.4.1.150

Accepted Name
N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase
Alternative Name(s)
I-branching beta1,6-N-acetylglucosaminyltransferase
N-acetylglucosaminyltransferase
Reaction catalysed
a beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + UDP-N-acetyl-alpha-D-glucosamine <=> a beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-[beta-D-GlcNAc-(1->6)]-beta-D-Gal-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP
Comment(s)
  • The enzyme acts on poly-N-acetyllactosamine [glycan chains of beta-D- galactosyl-(1->4)-N-acetyl-D-glucosamine units connected by beta(1,3) linkages] attached to proteins or lipids.
  • It transfers a GlcNAc residue by beta(1,6) linkage to galactosyl residues close to non-reducing terminals, introducing a branching pattern known as I branching.
  • Formerly EC 2.4.1.164.
Cross-references
BRENDA2.4.1.150
EC2PDB2.4.1.150
ExplorEnz2.4.1.150
PRIAM enzyme-specific profiles2.4.1.150
KEGG Ligand Database for Enzyme Nomenclature2.4.1.150
IUBMB Enzyme Nomenclature2.4.1.150
IntEnz2.4.1.150
MEDLINEFind literature relating to 2.4.1.150
MetaCyc2.4.1.150
Rhea expert-curated reactions2.4.1.150
UniProtKB/Swiss-Prot
P97402, GCNT2_MOUSEQ80RC7, GCNT3_BHV4Q99CW3, GCNT3_BHV4D
Q805R1, GCNT3_BHV4LQ9IZK2, GCNT3_BHV4VQ866Z5, GCNT3_BOSMU
Q7YQE1, GCNT3_BOVINQ1M0V6, GCNT3_BUBBUO95395, GCNT3_HUMAN
Q5JCT0, GCNT3_MOUSEQ8CH87, GCNT3_RATQ866Z6, GCNT3_SHEEP
Q866Z4, GCNT3_SYNCAQ5U258, GCNT3_XENLAQ8N0V5, GNT2A_HUMAN

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.1.-
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