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ENZYME entry: EC 2.4.1.150
Accepted Name |
N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase.
|
Alternative Name(s) |
I-branching beta1,6-N-acetylglucosaminyltransferase. |
N-acetylglucosaminyltransferase. |
Reaction catalysed |
a beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc derivative + UDP-N-acetyl-alpha-D-glucosamine <=> a beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-[beta-D-GlcNAc-(1->6)]-beta-D-Gal-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP |
Comment(s) |
- The enzyme acts on poly-N-acetyllactosamine [glycan chains of beta-D-
galactosyl-(1->4)-N-acetyl-D-glucosamine units connected by beta(1,3)
linkages] attached to proteins or lipids.
- It transfers a GlcNAc residue by beta(1,6) linkage to galactosyl
residues close to non-reducing terminals, introducing a branching
pattern known as I branching.
- Formerly EC 2.4.1.164.
|
Cross-references |
BRENDA | 2.4.1.150 |
EC2PDB | 2.4.1.150 |
ExplorEnz | 2.4.1.150 |
PRIAM enzyme-specific profiles | 2.4.1.150 |
KEGG Ligand Database for Enzyme Nomenclature | 2.4.1.150 |
IUBMB Enzyme Nomenclature | 2.4.1.150 |
IntEnz | 2.4.1.150 |
MEDLINE | Find literature relating to 2.4.1.150 |
MetaCyc | 2.4.1.150 |
Rhea expert-curated reactions | 2.4.1.150 |
UniProtKB/Swiss-Prot |
P97402, GCNT2_MOUSE; | Q80RC7, GCNT3_BHV4; | Q99CW3, GCNT3_BHV4D; |
Q805R1, GCNT3_BHV4L; | Q9IZK2, GCNT3_BHV4V; | Q866Z5, GCNT3_BOSMU; |
Q7YQE1, GCNT3_BOVIN; | Q1M0V6, GCNT3_BUBBU; | O95395, GCNT3_HUMAN; |
Q5JCT0, GCNT3_MOUSE; | Q8CH87, GCNT3_RAT; | Q866Z6, GCNT3_SHEEP; |
Q866Z4, GCNT3_SYNCA; | Q5U258, GCNT3_XENLA; | Q8N0V5, GNT2A_HUMAN; |
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ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 2.4.1.-
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