ENZYME entry: EC 2.4.1.150
| Accepted Name |
|---|
| N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase.
|
| Alternative Name(s) |
|---|
| I-branching beta-1,6-N-acetylglucosaminyltransferase. |
| N-acetylglucosaminyltransferase. |
| Reaction catalysed |
|---|
| UDP-N-acetyl-alpha-D-glucosamine + beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-beta-D-Gal-(1->4)-beta-D-GlcNAc-R <=> UDP + beta-D-Gal-(1->4)-beta-D-GlcNAc-(1->3)-(beta-D-GlcNAc-(1->6))-beta-D-Gal-(1->4)-beta-D-GlcNAc-R |
| Comment(s) |
|---|
- The enzyme acts on poly-N-acetyllactosamine (glycan chains of beta-D-
galactosyl-(1->4)-N-acetyl-D-glucosamine units connected by beta(1,3)
linkages) attached to proteins or lipids.
- It transfers a GlcNAc residue by beta(1,6) linkage to galactosyl
residues close to non-reducing terminals, introducing a branching
pattern known as I branching.
|
| Cross-references |
|---|
| BRENDA | 2.4.1.150 |
| EC2PDB | 2.4.1.150 |
| ExplorEnz | 2.4.1.150 |
| PRIAM enzyme-specific profiles | 2.4.1.150 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.4.1.150 |
| IUBMB Enzyme Nomenclature | 2.4.1.150 |
| IntEnz | 2.4.1.150 |
| MEDLINE | Find literature relating to 2.4.1.150 |
| MetaCyc | 2.4.1.150 |
| Rhea expert-curated reactions | 2.4.1.150 |
| UniProtKB/Swiss-Prot |
| P97402, GCNT2_MOUSE; | Q80RC7, GCNT3_BHV4; | Q99CW3, GCNT3_BHV4D; |
| Q805R1, GCNT3_BHV4L; | Q9IZK2, GCNT3_BHV4V; | Q866Z5, GCNT3_BOSMU; |
| Q7YQE1, GCNT3_BOVIN; | Q1M0V6, GCNT3_BUBBU; | O95395, GCNT3_HUMAN; |
| Q5JCT0, GCNT3_MOUSE; | Q8CH87, GCNT3_RAT; | Q866Z6, GCNT3_SHEEP; |
| Q866Z4, GCNT3_SYNCA; | Q5U258, GCNT3_XENLA; | Q8N0V5, GNT2A_HUMAN; |
|
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