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ENZYME entry: EC 2.4.1.155

Accepted Name
alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase.
Alternative Name(s)
alpha-1,3(6)-mannosylglycoprotein beta-1,6-N- acetylglucosaminyltransferase.
alpha-mannoside beta-1,6-N-acetylglucosaminyltransferase.
GlcNAc-T V.
GnTV.
N-acetylglucosaminyltransferase V.
UDP-N-acetylglucosamine:alpha-mannoside-beta1,6 N-acetylglucosaminyltransferase.
uridine diphosphoacetylglucosamine-alpha-mannoside beta1->6-acetylglucosaminyltransferase.
Reaction catalysed
N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAcl-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAcl-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP
Comment(s)
  • The enzyme, found in vertebrates, participates in the processing of N-glycans in the Golgi apparatus.
  • It catalyzes the addition of N-acetylglucosamine in beta 1-6 linkage to the alpha-linked mannose of biantennary N-linked oligosaccharides, and thus enables the synthesis of tri- and tetra-antennary complexes.
Cross-references
BRENDA2.4.1.155
EC2PDB2.4.1.155
ExplorEnz2.4.1.155
PRIAM enzyme-specific profiles2.4.1.155
KEGG Ligand Database for Enzyme Nomenclature2.4.1.155
IUBMB Enzyme Nomenclature2.4.1.155
IntEnz2.4.1.155
MEDLINEFind literature relating to 2.4.1.155
MetaCyc2.4.1.155
Rhea expert-curated reactions2.4.1.155
UniProtKB/Swiss-Prot
Q9NDH7, GLY2_CAEEL;  P97259, MGT5A_CRIGR;  Q09328, MGT5A_HUMAN;  
Q8R4G6, MGT5A_MOUSE;  Q08834, MGT5A_RAT;  Q3V5L5, MGT5B_HUMAN;  
Q765H6, MGT5B_MOUSE;  

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