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ENZYME

ENZYME entry: EC 2.4.1.165

PURL: https://purl.expasy.org/enzyme/EC/2.4.1.165
Accepted Name
N-acetylneuraminylgalactosylglucosyl-glucoside beta-1,4-N- acetylgalactosaminyltransferase
Alternative Name(s)
N-acetylneuraminylgalactosylglucosylceramide beta-1,4-N- acetylgalactosaminyltransferase
Reaction catalysed
an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl derivative + UDP-N-acetyl-alpha-D-galactosamine = an N-acetyl-beta-D-galactosaminyl-(1->4)-[N-acetyl-alpha-neuraminyl-(2->3)]-beta-D-galactosyl derivative + UDP + H(+)
Comment(s)
  • Requires Mn(2+).
  • The enzyme, found in mammals, is only active with substrates containing (2->3) linked sialic acid residues.
  • It is active with glycoproteins, but not with gangliosides. The enzyme is involved in synthesis of the blood group antigen Sd(a).
Cross-references
BRENDA2.4.1.165
EC2PDB2.4.1.165
ExplorEnz2.4.1.165
KEGG Ligand Database for Enzyme Nomenclature2.4.1.165
IUBMB Enzyme Nomenclature2.4.1.165
MEDLINEFind literature relating to 2.4.1.165
MetaCyc2.4.1.165
Rhea expert-curated reactions2.4.1.165

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-