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ENZYME entry: EC 2.4.1.175

Accepted Name
glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N- acetylgalactosaminyltransferase.
Alternative Name(s)
chondroitin synthase.
glucuronyl-N-acetylgalactosaminylproteoglycan beta-1,4-N- acetylgalactosaminyltransferase.
N-acetylgalactosaminyltransferase II.
UDP-N-acetyl-D-galactosamine:D-glucuronyl-N-acetyl-1,3-beta-D- galactosaminylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase.
uridine diphosphoacetylgalactosamine-chondroitin acetylgalactosaminyltransferase II.
Reaction catalysed
  • 3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine <=> 3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP
  • 3-O-(beta-D-GlcA-(1->3)-[beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine <=> 3-O-([beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n+1)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP
Comment(s)
  • Involved in the biosynthesis of chondroitin sulfate.
  • The human form of this enzyme is a bifunctional glycosyltransferase, which also has the EC 2.4.1.226 activity required for the synthesis of the chondroitin sulfate disaccharide repeats.
  • Similar chondroitin synthase 'copolymerases' can be found in Pasteurella multocida and Escherichia coli.
Cross-references
BRENDA2.4.1.175
EC2PDB2.4.1.175
ExplorEnz2.4.1.175
PRIAM enzyme-specific profiles2.4.1.175
KEGG Ligand Database for Enzyme Nomenclature2.4.1.175
IUBMB Enzyme Nomenclature2.4.1.175
IntEnz2.4.1.175
MEDLINEFind literature relating to 2.4.1.175
MetaCyc2.4.1.175
Rhea expert-curated reactions2.4.1.175
UniProtKB/Swiss-Prot
Q86X52, CHSS1_HUMAN;  Q6ZQ11, CHSS1_MOUSE;  Q8IZ52, CHSS2_HUMAN;  
Q6IQX7, CHSS2_MOUSE;  Q70JA7, CHSS3_HUMAN;  Q5DTK1, CHSS3_MOUSE;  
Q7Z1Z1, CHSSA_CAEEL;  P45895, CHSSB_CAEEL;  Q8L0V4, CHS_ECOLX;  
Q9CMP0, CHS_PASMU;  

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