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ENZYME entry: EC 2.4.1.175
Accepted Name |
glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-
acetylgalactosaminyltransferase.
|
Alternative Name(s) |
chondroitin synthase. |
glucuronyl-N-acetylgalactosaminylproteoglycan beta-1,4-N-
acetylgalactosaminyltransferase. |
N-acetylgalactosaminyltransferase II. |
UDP-N-acetyl-D-galactosamine:D-glucuronyl-N-acetyl-1,3-beta-D-
galactosaminylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase. |
uridine diphosphoacetylgalactosamine-chondroitin
acetylgalactosaminyltransferase II. |
Reaction catalysed |
- 3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine <=> 3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP
- 3-O-(beta-D-GlcA-(1->3)-[beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + UDP-N-acetyl-alpha-D-galactosamine <=> 3-O-([beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)](n+1)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-seryl-[protein] + H(+) + UDP
|
Comment(s) |
- Involved in the biosynthesis of chondroitin sulfate.
- The human form of this enzyme is a bifunctional glycosyltransferase,
which also has the EC 2.4.1.226 activity required for the synthesis
of the chondroitin sulfate disaccharide repeats.
- Similar chondroitin synthase 'copolymerases' can be found in
Pasteurella multocida and Escherichia coli.
|
Cross-references |
BRENDA | 2.4.1.175 |
EC2PDB | 2.4.1.175 |
ExplorEnz | 2.4.1.175 |
PRIAM enzyme-specific profiles | 2.4.1.175 |
KEGG Ligand Database for Enzyme Nomenclature | 2.4.1.175 |
IUBMB Enzyme Nomenclature | 2.4.1.175 |
IntEnz | 2.4.1.175 |
MEDLINE | Find literature relating to 2.4.1.175 |
MetaCyc | 2.4.1.175 |
Rhea expert-curated reactions | 2.4.1.175 |
UniProtKB/Swiss-Prot |
Q86X52, CHSS1_HUMAN; | Q6ZQ11, CHSS1_MOUSE; | Q8IZ52, CHSS2_HUMAN; |
Q6IQX7, CHSS2_MOUSE; | Q70JA7, CHSS3_HUMAN; | Q5DTK1, CHSS3_MOUSE; |
Q7Z1Z1, CHSSA_CAEEL; | P45895, CHSSB_CAEEL; | Q8L0V4, CHS_ECOLX; |
Q9CMP0, CHS_PASMU; |
|
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