A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 2.4.1.175
| Accepted Name |
|---|
| Glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-
acetylgalactosaminyltransferase.
|
| Alternative Name(s) |
|---|
| Chondroitin synthase. |
| Glucuronyl-N-acetylgalactosaminylproteoglycan beta-1,4-N-
acetylgalactosaminyltransferase. |
| N-acetylgalactosaminyltransferase II. |
| UDP-N-acetyl-D-galactosamine:D-glucuronyl-N-acetyl-1,3-beta-D-
galactosaminylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase. |
| Uridine diphosphoacetylgalactosamine-chondroitin
acetylgalactosaminyltransferase II. |
| Reaction catalysed |
|---|
- UDP-N-acetyl-alpha-D-galactosamine + [protein]-3-O-(beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine <=> UDP + [protein]-3-O-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine
- UDP-N-acetyl-alpha-D-galactosamine + [protein]-3-O-(beta-D-GlcA-(1->3)-(beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3))(n)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine <=> UDP + [protein]-3-O-((beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3))(n+1)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-beta-D-Xyl)-L-serine
|
| Comment(s) |
|---|
- Involved in the biosynthesis of chondroitin sulfate.
- The human form of this enzyme is a bifunctional glycosyltransferase,
which also has the EC 2.4.1.226 activity required for the synthesis
of the chondroitin sulfate disaccharide repeats.
- Similar chondroitin synthase 'copolymerases' can be found in
Pasteurella multocida and Escherichia coli.
|
| Cross-references |
|---|
| BRENDA | 2.4.1.175 |
| EC2PDB | 2.4.1.175 |
| ExplorEnz | 2.4.1.175 |
| PRIAM enzyme-specific profiles | 2.4.1.175 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.4.1.175 |
| IUBMB Enzyme Nomenclature | 2.4.1.175 |
| IntEnz | 2.4.1.175 |
| MEDLINE | Find literature relating to 2.4.1.175 |
| MetaCyc | 2.4.1.175 |
| UniProtKB/Swiss-Prot |
| Q86X52, CHSS1_HUMAN; | Q6ZQ11, CHSS1_MOUSE; | Q8IZ52, CHSS2_HUMAN; |
| Q6IQX7, CHSS2_MOUSE; | Q70JA7, CHSS3_HUMAN; | Q5DTK1, CHSS3_MOUSE; |
| Q7Z1Z1, CHSSA_CAEEL; | P45895, CHSSB_CAEEL; | Q8L0V4, CHS_ECOLX; |
| Q9CMP0, CHS_PASMU; |
|
View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot
entries referenced
in this entry, with possibility to download in different formats, align etc.
All
ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 2.4.1.-
All
ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 2.4.-.-
All
ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-