ENZYME entry: EC 2.4.1.198

Accepted Name

phosphatidylinositol N-acetylglucosaminyltransferase

Alternative Name(s)

UDP-N-acetyl-D-glucosamine:phosphatidylinositol N-acetyl-D- glucosaminyltransferase

uridine diphosphoacetylglucosamine alpha1,6-acetyl-D- glucosaminyltransferase

Reaction catalysed

a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + UDP-N-acetyl-alpha-D-glucosamine = a 6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + UDP + H(+)

Comment(s)

Involved in the first step of glycosylphosphatidylinositol (GPI) anchor formation in all eukaryotes.
In mammalian cells, the enzyme is composed of at least five subunits (PIG-A, PIG-H, PIG-C, GPI1 and PIG-P).
PIG-A subunit is the catalytic subunit.
In some species, the long-chain acyl groups of the phosphatidyl group are partly replaced by long-chain alkyl or alk-1-enyl groups.

Cross-references

BRENDA

2.4.1.198

EC2PDB

2.4.1.198

ExplorEnz

2.4.1.198

KEGG Ligand Database for Enzyme Nomenclature

2.4.1.198

IUBMB Enzyme Nomenclature

2.4.1.198

MEDLINE

Find literature relating to 2.4.1.198

MetaCyc

2.4.1.198

Rhea expert-curated reactions

2.4.1.198

UniProtKB/Swiss-Prot

Q9Y7L7, GPI15_SCHPO	P53961, GPI15_YEAST	Q756D4, GPI19_EREGS
Q04082, GPI19_YEAST	P53306, GPI1_YEAST	O59802, GPI2_SCHPO
P46961, GPI2_YEAST	P87172, GPI3_SCHPO	B3LKQ3, GPI3_YEAS1
B5VSZ6, GPI3_YEAS6	A6ZW78, GPI3_YEAS7	P32363, GPI3_YEAST
Q94BX4, PIGA_ARATH	P37287, PIGA_HUMAN	Q64323, PIGA_MOUSE
O64761, PIGC_ARATH	Q54M40, PIGC_DICDI	O64792, PIGP_ARATH

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