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ENZYME

ENZYME entry: EC 2.4.1.198

PURL: https://purl.expasy.org/enzyme/EC/2.4.1.198
Accepted Name
phosphatidylinositol N-acetylglucosaminyltransferase
Alternative Name(s)
UDP-N-acetyl-D-glucosamine:phosphatidylinositol N-acetyl-D- glucosaminyltransferase
uridine diphosphoacetylglucosamine alpha1,6-acetyl-D- glucosaminyltransferase
Reaction catalysed
a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + UDP-N-acetyl-alpha-D-glucosamine = a 6-(N-acetyl-alpha-D-glucosaminyl)-1-(1,2-diacyl-sn-glycero-3-phospho)-1D-myo-inositol + UDP + H(+)
Comment(s)
  • Involved in the first step of glycosylphosphatidylinositol (GPI) anchor formation in all eukaryotes.
  • In mammalian cells, the enzyme is composed of at least five subunits (PIG-A, PIG-H, PIG-C, GPI1 and PIG-P).
  • PIG-A subunit is the catalytic subunit.
  • In some species, the long-chain acyl groups of the phosphatidyl group are partly replaced by long-chain alkyl or alk-1-enyl groups.
Cross-references
BRENDA2.4.1.198
EC2PDB2.4.1.198
ExplorEnz2.4.1.198
KEGG Ligand Database for Enzyme Nomenclature2.4.1.198
IUBMB Enzyme Nomenclature2.4.1.198
MEDLINEFind literature relating to 2.4.1.198
MetaCyc2.4.1.198
Rhea expert-curated reactions2.4.1.198
UniProtKB/Swiss-Prot
Q9Y7L7, GPI15_SCHPOP53961, GPI15_YEASTQ756D4, GPI19_EREGS
Q04082, GPI19_YEASTP53306, GPI1_YEASTO59802, GPI2_SCHPO
P46961, GPI2_YEASTP87172, GPI3_SCHPOB3LKQ3, GPI3_YEAS1
B5VSZ6, GPI3_YEAS6A6ZW78, GPI3_YEAS7P32363, GPI3_YEAST
Q94BX4, PIGA_ARATHP37287, PIGA_HUMANQ64323, PIGA_MOUSE
O64761, PIGC_ARATHQ54M40, PIGC_DICDIO64792, PIGP_ARATH

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