ENZYME

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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 2.4.1.201

Accepted Name

Alpha-1,6-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase.

Alternative Name(s)

GlcNAc-T VI.

GnTVI.

Mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase.

N-acetylglucosaminyltransferase VI.

N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase VI.

Uridine diphosphoacetylglucosamine-glycopeptide beta- 1->4-acetylglucosaminyltransferase VI.

Reaction catalysed

UDP-N-acetyl-alpha-D-glucosamine + beta-D-GlcNAc-(1->2)-(beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-(beta-D-GlcNAc-(1->2)-(beta-D-GlcNAc-(1->6))-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[protein] <=> UDP + beta-D-GlcNAc-(1->2)-(beta-D-GlcNAc-(1->4))-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4))-(beta-D-GlcNAc-(1->6))-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[protein]

Comment(s)

The enzyme, characterized from hen oviduct membranes, participates in the processing of N-glycans in the Golgi apparatus.
It transfers GlcNAc in beta-1-4 linkage to a D-mannose residue that already has GlcNAc residues attached at positions 2 and 6 by beta linkages.
No homologous enzyme appears to exist in mammals.

Cross-references

BRENDA

2.4.1.201

EC2PDB

2.4.1.201

ExplorEnz

2.4.1.201

PRIAM enzyme-specific profiles

2.4.1.201

KEGG Ligand Database for Enzyme Nomenclature

2.4.1.201

IUBMB Enzyme Nomenclature