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ENZYME

ENZYME entry: EC 2.4.1.201

PURL: https://purl.expasy.org/enzyme/EC/2.4.1.201
Accepted Name
alpha-1,6-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase
Alternative Name(s)
GlcNAc-T VI
GnTVI
mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase
N-acetylglucosaminyltransferase VI
N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase VI
uridine diphosphoacetylglucosamine-glycopeptide beta- 1->4-acetylglucosaminyltransferase VI
Reaction catalysed
N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine = N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP + H(+)
Comment(s)
  • The enzyme, characterized from hen oviduct membranes, participates in the processing of N-glycans in the Golgi apparatus.
  • It transfers GlcNAc in beta1-4 linkage to a D-mannose residue that already has GlcNAc residues attached at positions 2 and 6 by beta linkages.
  • No homologous enzyme appears to exist in mammals.
Cross-references
BRENDA2.4.1.201
EC2PDB2.4.1.201
ExplorEnz2.4.1.201
KEGG Ligand Database for Enzyme Nomenclature2.4.1.201
IUBMB Enzyme Nomenclature2.4.1.201
MEDLINEFind literature relating to 2.4.1.201
MetaCyc2.4.1.201
Rhea expert-curated reactions2.4.1.201
UniProtKB/Swiss-Prot
Q9DGD1, MGT4C_CHICK

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