ENZYME entry: EC 2.4.1.201
| Accepted Name |
|---|
| alpha-1,6-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase.
|
| Alternative Name(s) |
|---|
| GlcNAc-T VI. |
| GnTVI. |
| mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase. |
| N-acetylglucosaminyltransferase VI. |
| N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase
VI. |
| uridine diphosphoacetylglucosamine-glycopeptide beta-
1->4-acetylglucosaminyltransferase VI. |
| Reaction catalysed |
|---|
| N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAcl-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP |
| Comment(s) |
|---|
- The enzyme, characterized from hen oviduct membranes, participates in
the processing of N-glycans in the Golgi apparatus.
- It transfers GlcNAc in beta1-4 linkage to a D-mannose residue that
already has GlcNAc residues attached at positions 2 and 6 by beta
linkages.
- No homologous enzyme appears to exist in mammals.
|
| Cross-references |
|---|
| BRENDA | 2.4.1.201 |
| EC2PDB | 2.4.1.201 |
| ExplorEnz | 2.4.1.201 |
| PRIAM enzyme-specific profiles | 2.4.1.201 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.4.1.201 |
| IUBMB Enzyme Nomenclature | 2.4.1.201 |
| IntEnz | 2.4.1.201 |
| MEDLINE | Find literature relating to 2.4.1.201 |
| MetaCyc | 2.4.1.201 |
| Rhea expert-curated reactions | 2.4.1.201 |
| UniProtKB/Swiss-Prot |
|
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