ENZYME entry: EC 2.4.1.201
Accepted Name |
alpha-1,6-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase.
|
Alternative Name(s) |
GlcNAc-T VI. |
GnTVI. |
mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase. |
N-acetylglucosaminyltransferase VI. |
N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase
VI. |
uridine diphosphoacetylglucosamine-glycopeptide beta-
1->4-acetylglucosaminyltransferase VI. |
Reaction catalysed |
N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAcl-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP-N-acetyl-alpha-D-glucosamine <=> H(+) + N(4)-{beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4)]-[beta-D-GlcNAc-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc}-L-asparaginyl-[protein] + UDP |
Comment(s) |
- The enzyme, characterized from hen oviduct membranes, participates in
the processing of N-glycans in the Golgi apparatus.
- It transfers GlcNAc in beta1-4 linkage to a D-mannose residue that
already has GlcNAc residues attached at positions 2 and 6 by beta
linkages.
- No homologous enzyme appears to exist in mammals.
|
Cross-references |
BRENDA | 2.4.1.201 |
EC2PDB | 2.4.1.201 |
ExplorEnz | 2.4.1.201 |
PRIAM enzyme-specific profiles | 2.4.1.201 |
KEGG Ligand Database for Enzyme Nomenclature | 2.4.1.201 |
IUBMB Enzyme Nomenclature | 2.4.1.201 |
IntEnz | 2.4.1.201 |
MEDLINE | Find literature relating to 2.4.1.201 |
MetaCyc | 2.4.1.201 |
Rhea expert-curated reactions | 2.4.1.201 |
UniProtKB/Swiss-Prot |
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