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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 2.4.1.201

Accepted Name
Alpha-1,6-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase.
Alternative Name(s)
GlcNAc-T VI.
GnTVI.
Mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase.
N-acetylglucosaminyltransferase VI.
N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase VI.
Uridine diphosphoacetylglucosamine-glycopeptide beta- 1->4-acetylglucosaminyltransferase VI.
Reaction catalysed
UDP-N-acetyl-alpha-D-glucosamine + beta-D-GlcNAc-(1->2)-(beta-D-GlcNAc-(1->4)]-alpha-D-Man-(1->3)-(beta-D-GlcNAc-(1->2)-(beta-D-GlcNAc-(1->6))-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[protein] <=> UDP + beta-D-GlcNAc-(1->2)-(beta-D-GlcNAc-(1->4))-alpha-D-Man-(1->3)-[beta-D-GlcNAc-(1->2)-[beta-D-GlcNAc-(1->4))-(beta-D-GlcNAc-(1->6))-alpha-D-Man-(1->6))-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-beta-D-GlcNAc-N-Asn-[protein]
Comment(s)
  • The enzyme, characterized from hen oviduct membranes, participates in the processing of N-glycans in the Golgi apparatus.
  • It transfers GlcNAc in beta-1-4 linkage to a D-mannose residue that already has GlcNAc residues attached at positions 2 and 6 by beta linkages.
  • No homologous enzyme appears to exist in mammals.
Cross-references
BRENDA2.4.1.201
EC2PDB2.4.1.201
ExplorEnz2.4.1.201
PRIAM enzyme-specific profiles2.4.1.201
KEGG Ligand Database for Enzyme Nomenclature2.4.1.201
IUBMB Enzyme Nomenclature2.4.1.201
IntEnz2.4.1.201
MEDLINEFind literature relating to 2.4.1.201
MetaCyc2.4.1.201
UniProtKB/Swiss-Prot
Q9DGD1, MGT4C_CHICK

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-