ID   2.4.1.212
DE   Hyaluronan synthase.
AN   HAS.
CA   (1) UDP-alpha-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->3)-N-
CA   acetyl-beta-D-glucosaminyl-(1->4)-(nascent hyaluronan) = UDP + N-acetyl-
CA   beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-
CA   glucosaminyl-(1->4)-(nascent hyaluronan).
CA   (2) UDP-alpha-D-glucuronate + N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-
CA   glucuronosyl-(1->3)-(nascent hyaluronan) = UDP + beta-D-glucuronosyl-
CA   (1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-
CA   (nascent hyaluronan).
CF   Mg(2+).
CC   -!- Adds GlcNAc to nascent hyaluronan when the non-reducing end is GlcA,
CC       but it adds GlcA when the non-reducing end is GlcNAc.
CC   -!- Highly specific for UDP-GlcNAc and UDP-GlcA; no copolymerization is
CC       observed if either is replaced by UDP-Glc, UDP-Gal, UDP-GalNAc or
CC       UDP-GalA.
DR   P0C0H1, HASA_STRP1 ;  P0DB60, HASA_STRP3 ;  Q5X9A9, HASA_STRP6 ;
DR   Q8NKX1, HASA_STRP8 ;  P0DB61, HASA_STRPQ ;  P0C0H0, HASA_STRPY ;
DR   Q7BLV3, HAS_PASMD  ;  Q92839, HYAS1_HUMAN;  Q61647, HYAS1_MOUSE;
DR   P13563, HYAS1_XENLA;  B1WB39, HYAS1_XENTR;  O97711, HYAS2_BOVIN;
DR   O57424, HYAS2_CHICK;  G5AY81, HYAS2_HETGA;  Q92819, HYAS2_HUMAN;
DR   P70312, HYAS2_MOUSE;  O35776, HYAS2_RAT  ;  O57427, HYAS2_XENLA;
DR   O57425, HYAS3_CHICK;  O00219, HYAS3_HUMAN;  O08650, HYAS3_MOUSE;
DR   O57426, HYAS3_XENLA;
//