ID 2.4.1.212 DE Hyaluronan synthase. AN HAS. CA (1) UDP-alpha-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->3)-N- CA acetyl-beta-D-glucosaminyl-(1->4)-(nascent hyaluronan) = UDP + N-acetyl- CA beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D- CA glucosaminyl-(1->4)-(nascent hyaluronan). CA (2) UDP-alpha-D-glucuronate + N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D- CA glucuronosyl-(1->3)-(nascent hyaluronan) = UDP + beta-D-glucuronosyl- CA (1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)- CA (nascent hyaluronan). CF Mg(2+). CC -!- Adds GlcNAc to nascent hyaluronan when the non-reducing end is GlcA, CC but it adds GlcA when the non-reducing end is GlcNAc. CC -!- Highly specific for UDP-GlcNAc and UDP-GlcA; no copolymerization is CC observed if either is replaced by UDP-Glc, UDP-Gal, UDP-GalNAc or CC UDP-GalA. DR P0C0H1, HASA_STRP1 ; P0DB60, HASA_STRP3 ; Q5X9A9, HASA_STRP6 ; DR Q8NKX1, HASA_STRP8 ; P0DB61, HASA_STRPQ ; P0C0H0, HASA_STRPY ; DR Q7BLV3, HAS_PASMD ; Q92839, HYAS1_HUMAN; Q61647, HYAS1_MOUSE; DR P13563, HYAS1_XENLA; B1WB39, HYAS1_XENTR; O97711, HYAS2_BOVIN; DR O57424, HYAS2_CHICK; G5AY81, HYAS2_HETGA; Q92819, HYAS2_HUMAN; DR P70312, HYAS2_MOUSE; O35776, HYAS2_RAT ; O57427, HYAS2_XENLA; DR O57425, HYAS3_CHICK; O00219, HYAS3_HUMAN; O08650, HYAS3_MOUSE; DR O57426, HYAS3_XENLA; //