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ENZYME entry: EC 2.4.1.22

Accepted Name
lactose synthase.
Alternative Name(s)
N-acetyllactosamine synthase.
UDP-galactose--glucose galactosyltransferase.
Reaction catalysed
D-glucose + UDP-alpha-D-galactose <=> H(+) + lactose + UDP
Comment(s)
  • The enzyme is a complex of 2 proteins A and B.
  • In the absence of the B protein (alpha-lactalbumin) the enzyme catalyzes the transfer of galactose from UDP-galactose to N-acetylglucosamine (cf. EC 2.4.1.90).
Cross-references
BRENDA2.4.1.22
EC2PDB2.4.1.22
ExplorEnz2.4.1.22
PRIAM enzyme-specific profiles2.4.1.22
KEGG Ligand Database for Enzyme Nomenclature2.4.1.22
IUBMB Enzyme Nomenclature2.4.1.22
IntEnz2.4.1.22
MEDLINEFind literature relating to 2.4.1.22
MetaCyc2.4.1.22
Rhea expert-curated reactions2.4.1.22
UniProtKB/Swiss-Prot
P08037, B4GT1_BOVIN;  P15291, B4GT1_HUMAN;  P15535, B4GT1_MOUSE;  
P80225, B4GT1_RAT;  Q80WN9, B4GT2_CRIGR;  O60909, B4GT2_HUMAN;  
Q9Z2Y2, B4GT2_MOUSE;  

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