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ENZYME

ENZYME entry: EC 2.4.1.244

Accepted Name
N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N- acetylgalactosaminyltransferase
Alternative Name(s)
beta1,4-N-acetylgalactosaminyltransferase
beta4GalNAc-T3
beta4GalNAc-T4
Reaction catalysed
an N-acetyl-beta-D-glucosaminyl derivative + UDP-N-acetyl-alpha-D-galactosamine = an N-acetyl-beta-D-galactosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP + H(+)
Comment(s)
  • The enzyme from human can transfer N-acetyl-D-galactosamine (GalNAc) to N-glycan and O-glycan substrates that have N-acetyl-D-glucosamine (GlcNAc) but not D-glucuronic acid (GlcUA) at their non-reducing end.
  • The N-acetyl-beta-D-glucosaminyl group is normally on a core oligosaccharide although benzyl glycosides have been used in enzyme- characterization experiments.
  • Some glycohormones, e.g. lutropin and thyrotropin contain the N-glycan structure containing the N-acetyl-beta-D-galactosaminyl- (1->4)-N-acetyl-beta-D-glucosaminyl group.
Cross-references
BRENDA2.4.1.244
EC2PDB2.4.1.244
ExplorEnz2.4.1.244
PRIAM enzyme-specific profiles2.4.1.244
KEGG Ligand Database for Enzyme Nomenclature2.4.1.244
IUBMB Enzyme Nomenclature2.4.1.244
IntEnz2.4.1.244
MEDLINEFind literature relating to 2.4.1.244
MetaCyc2.4.1.244
Rhea expert-curated reactions2.4.1.244
UniProtKB/Swiss-Prot
Q6L9W6, B4GN3_HUMANQ6L8S8, B4GN3_MOUSEQ76KP1, B4GN4_HUMAN
Q766D5, B4GN4_MOUSE

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