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ENZYME entry: EC 2.4.1.250

Accepted Name
D-inositol-3-phosphate glycosyltransferase.
Alternative Name(s)
mycothiol glycosyltransferase.
N-acetylglucosamine-inositol-phosphate N-acetylglucosaminyltransferase.
Reaction catalysed
1D-myo-inositol 3-phosphate + UDP-N-acetyl-alpha-D-glucosamine <=> 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside 3-phosphate + H(+) + UDP
Comment(s)
  • The enzyme, which belongs to the GT-B fold superfamily, catalyzes the first dedicated reaction in the biosynthesis of mycothiol.
  • The substrate was initially believed to be inositol, but eventually shown to be D-myo-inositol 3-phosphate.
  • A substantial conformational change occurs upon UDP binding, which generates the binding site for D-myo-inositol 3-phosphate.
  • Formerly EC 2.4.1.n3.
Cross-references
BRENDA2.4.1.250
EC2PDB2.4.1.250
ExplorEnz2.4.1.250
PRIAM enzyme-specific profiles2.4.1.250
KEGG Ligand Database for Enzyme Nomenclature2.4.1.250
IUBMB Enzyme Nomenclature2.4.1.250
IntEnz2.4.1.250
MEDLINEFind literature relating to 2.4.1.250
MetaCyc2.4.1.250
Rhea expert-curated reactions2.4.1.250
UniProtKB/Swiss-Prot
C7Q4Y6, MSHA1_CATAD;  C7QKE8, MSHA2_CATAD;  A0LQY9, MSHA_ACIC1;  
C6WPK3, MSHA_ACTMD;  A0JZ09, MSHA_ARTS2;  D5UJ42, MSHA_CELFN;  
C3PK12, MSHA_CORA7;  Q6NJL3, MSHA_CORDI;  Q8FSH1, MSHA_COREF;  
A4QB40, MSHA_CORGB;  Q8NTA6, MSHA_CORGL;  Q4JSW2, MSHA_CORJK;  
C4LLD6, MSHA_CORK4;  B1VEI4, MSHA_CORU7;  Q0RS49, MSHA_FRAAA;  
Q2JFV0, MSHA_FRACC;  A8LDJ8, MSHA_FRASN;  D2S4K7, MSHA_GEOOG;  
D0L476, MSHA_GORB4;  C7R101, MSHA_JONDD;  A6W6D9, MSHA_KINRD;  
D2Q1C4, MSHA_KRIFD;  A0QLK5, MSHA_MYCA1;  B1MHQ0, MSHA_MYCA9;  
P64708, MSHA_MYCBO;  A1KFW0, MSHA_MYCBP;  C1AKG4, MSHA_MYCBT;  
A4T324, MSHA_MYCGI;  B8ZT88, MSHA_MYCLB;  P54138, MSHA_MYCLE;  
B2HQV2, MSHA_MYCMM;  Q73SU4, MSHA_MYCPA;  A0QQZ8, MSHA_MYCS2;  
A3PU84, MSHA_MYCSJ;  A1UAM8, MSHA_MYCSK;  Q1BEA6, MSHA_MYCSS;  
A5TZL4, MSHA_MYCTA;  A5WJJ8, MSHA_MYCTF;  C6DT68, MSHA_MYCTK;  
P9WMY6, MSHA_MYCTO;  P9WMY7, MSHA_MYCTU;  A0PVZ1, MSHA_MYCUA;  
A1T3B5, MSHA_MYCVP;  C8XA09, MSHA_NAKMY;  D7AW65, MSHA_NOCDD;  
Q5YP47, MSHA_NOCFA;  A1SP12, MSHA_NOCSJ;  A1R8N8, MSHA_PAEAT;  
B8HCF8, MSHA_PSECP;  C0ZUT0, MSHA_RHOE4;  Q0SF06, MSHA_RHOJR;  
C1AZ64, MSHA_RHOOB;  A4FQ08, MSHA_SACEN;  C7MSY6, MSHA_SACVD;  
A8LZG1, MSHA_SALAI;  A4X1R6, MSHA_SALTO;  D1BD84, MSHA_SANKS;  
D6Z995, MSHA_SEGRD;  D3Q051, MSHA_STANL;  Q82G92, MSHA_STRAW;  
D7C367, MSHA_STRBB;  Q9FCG5, MSHA_STRCO;  B1VS68, MSHA_STRGG;  
D2B9F4, MSHA_STRRD;  C9ZH13, MSHA_STRSW;  D6Y4U7, MSHA_THEBD;  
D1A4Q3, MSHA_THECD;  Q47KS6, MSHA_THEFY;  D5USX8, MSHA_TSUPD;  
D1BZ82, MSHA_XYLCX;  

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