ENZYME entry: EC 2.4.1.250

Accepted Name

D-inositol-3-phosphate glycosyltransferase

Alternative Name(s)

mycothiol glycosyltransferase

N-acetylglucosamine-inositol-phosphate N-acetylglucosaminyltransferase

Reaction catalysed

1D-myo-inositol 3-phosphate + UDP-N-acetyl-alpha-D-glucosamine <=> 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside 3-phosphate + H(+) + UDP

Comment(s)

The enzyme, which belongs to the GT-B fold superfamily, catalyzes the first dedicated reaction in the biosynthesis of mycothiol.
The substrate was initially believed to be inositol, but eventually shown to be D-myo-inositol 3-phosphate.
A substantial conformational change occurs upon UDP binding, which generates the binding site for D-myo-inositol 3-phosphate.
Formerly EC 2.4.1.n3.

Cross-references

BRENDA

2.4.1.250

EC2PDB

2.4.1.250

ExplorEnz

2.4.1.250

PRIAM enzyme-specific profiles

2.4.1.250

KEGG Ligand Database for Enzyme Nomenclature

2.4.1.250

IUBMB Enzyme Nomenclature

2.4.1.250

IntEnz

2.4.1.250

MEDLINE

Find literature relating to 2.4.1.250

MetaCyc

2.4.1.250

Rhea expert-curated reactions

2.4.1.250

UniProtKB/Swiss-Prot

C7Q4Y6, MSHA1_CATAD	C7QKE8, MSHA2_CATAD	A0LQY9, MSHA_ACIC1
C6WPK3, MSHA_ACTMD	A0JZ09, MSHA_ARTS2	D5UJ42, MSHA_CELFN
C3PK12, MSHA_CORA7	Q6NJL3, MSHA_CORDI	Q8FSH1, MSHA_COREF
A4QB40, MSHA_CORGB	Q8NTA6, MSHA_CORGL	Q4JSW2, MSHA_CORJK
C4LLD6, MSHA_CORK4	B1VEI4, MSHA_CORU7	Q0RS49, MSHA_FRAAA
Q2JFV0, MSHA_FRACC	A8LDJ8, MSHA_FRASN	D2S4K7, MSHA_GEOOG
D0L476, MSHA_GORB4	C7R101, MSHA_JONDD	A6W6D9, MSHA_KINRD
D2Q1C4, MSHA_KRIFD	A0QLK5, MSHA_MYCA1	B1MHQ0, MSHA_MYCA9
P64708, MSHA_MYCBO	A1KFW0, MSHA_MYCBP	C1AKG4, MSHA_MYCBT
A4T324, MSHA_MYCGI	B8ZT88, MSHA_MYCLB	P54138, MSHA_MYCLE
B2HQV2, MSHA_MYCMM	Q73SU4, MSHA_MYCPA	A0QQZ8, MSHA_MYCS2
A3PU84, MSHA_MYCSJ	A1UAM8, MSHA_MYCSK	Q1BEA6, MSHA_MYCSS
A5TZL4, MSHA_MYCTA	A5WJJ8, MSHA_MYCTF	C6DT68, MSHA_MYCTK
P9WMY6, MSHA_MYCTO	P9WMY7, MSHA_MYCTU	A0PVZ1, MSHA_MYCUA
A1T3B5, MSHA_MYCVP	C8XA09, MSHA_NAKMY	D7AW65, MSHA_NOCDD
Q5YP47, MSHA_NOCFA	A1SP12, MSHA_NOCSJ	A1R8N8, MSHA_PAEAT
B8HCF8, MSHA_PSECP	C0ZUT0, MSHA_RHOE4	Q0SF06, MSHA_RHOJR
C1AZ64, MSHA_RHOOB	A4FQ08, MSHA_SACEN	C7MSY6, MSHA_SACVD
A8LZG1, MSHA_SALAI	A4X1R6, MSHA_SALTO	D1BD84, MSHA_SANKS
D6Z995, MSHA_SEGRD	D3Q051, MSHA_STANL	Q82G92, MSHA_STRAW
D7C367, MSHA_STRBB	Q9FCG5, MSHA_STRCO	B1VS68, MSHA_STRGG
D2B9F4, MSHA_STRRD	C9ZH13, MSHA_STRSW	D6Y4U7, MSHA_THEBD
D1A4Q3, MSHA_THECD	Q47KS6, MSHA_THEFY	D5USX8, MSHA_TSUPD
D1BZ82, MSHA_XYLCX

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.-.-
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