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ENZYME

ENZYME entry: EC 2.4.1.256

PURL: https://purl.expasy.org/enzyme/EC/2.4.1.256
Accepted Name
dolichyl-P-Glc:Glc2Man9GlcNAc2-PP-dolichol alpha-1,2-glucosyltransferase
Alternative Name(s)
Dol-P-Glc:Glc2Man9GlcNAc2-PP-Dol alpha1,2-glucosyltransferase
Reaction catalysed
an alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-glucosyl phosphate = a alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)
Comment(s)
  • This eukaryotic enzyme performs the final step in the synthesis of the lipid-linked oligosaccharide, attaching D-glucose in an alpha- 1,2-linkage to the outermost D-glucose in the long branch.
  • The lipid-linked oligosaccharide is involved in N-linked protein glycosylation of selected asparagine residues of nascent polypeptide chains in eukaryotic cells.
Cross-references
BRENDA2.4.1.256
EC2PDB2.4.1.256
ExplorEnz2.4.1.256
KEGG Ligand Database for Enzyme Nomenclature2.4.1.256
IUBMB Enzyme Nomenclature2.4.1.256
MEDLINEFind literature relating to 2.4.1.256
MetaCyc2.4.1.256
Rhea expert-curated reactions2.4.1.256
UniProtKB/Swiss-Prot
Q5BKT4, AG10A_HUMANQ5I7T1, AG10B_HUMANQ3UGP8, AG10B_MOUSE
O88788, AG10B_RATQ8L638, ALG10_ARATHQ4X162, ALG10_ASPFU
Q59YV2, ALG10_CANALQ6FL34, ALG10_CANGAQ6BW42, ALG10_DEBHA
Q8T8L8, ALG10_DROMEQ5B0M8, ALG10_EMENIQ75AQ8, ALG10_EREGS
Q4HZE0, ALG10_GIBZEQ6CN27, ALG10_KLULAQ4P2W6, ALG10_MYCMD
Q7SA35, ALG10_NEUCRP0C147, ALG10_PYRO7Q10254, ALG10_SCHPO
Q6CEA5, ALG10_YARLIP50076, ALG10_YEAST

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