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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 2.4.1.256

Accepted Name
Dolichyl-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-dolichol alpha-1,2- glucosyltransferase.
Alternative Name(s)
Dol-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-Dol alpha-1,2-glucosyltransferase.
Reaction catalysed
Dolichyl beta-D-glucosyl phosphate + D-Glc-alpha-(1->3)-D-Glc-alpha-(1->3)-D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->2)-D-Man-alpha-(1->6))-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol <=> D-Glc-alpha-(1->2)-D-Glc-alpha-(1->3)-D-Glc-alpha-(1->3)-D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->2)-D-Man-alpha-(1->6))-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate
Comment(s)
  • This eukaryotic enzyme performs the final step in the synthesis of the lipid-linked oligosaccharide, attaching D-glucose in an alpha- 1,2-linkage to the outermost D-glucose in the long branch.
  • The lipid-linked oligosaccharide is involved in N-linked protein glycosylation of selected asparagine residues of nascent polypeptide chains in eukaryotic cells.
Cross-references
BRENDA2.4.1.256
EC2PDB2.4.1.256
ExplorEnz2.4.1.256
PRIAM enzyme-specific profiles2.4.1.256
KEGG Ligand Database for Enzyme Nomenclature2.4.1.256
IUBMB Enzyme Nomenclature2.4.1.256
IntEnz2.4.1.256
MEDLINEFind literature relating to 2.4.1.256
MetaCyc2.4.1.256
UniProtKB/Swiss-Prot
Q5BKT4, AG10A_HUMAN;  Q5I7T1, AG10B_HUMAN;  Q3UGP8, AG10B_MOUSE;  
O88788, AG10B_RAT;  Q8L638, ALG10_ARATH;  Q75AQ8, ALG10_ASHGO;  
Q4X162, ALG10_ASPFU;  Q59YV2, ALG10_CANAL;  Q6FL34, ALG10_CANGA;  
Q6BW42, ALG10_DEBHA;  Q8T8L8, ALG10_DROME;  Q5B0M8, ALG10_EMENI;  
Q4HZE0, ALG10_GIBZE;  Q6CN27, ALG10_KLULA;  P0C147, ALG10_MAGO7;  
Q7SA35, ALG10_NEUCR;  Q10254, ALG10_SCHPO;  Q4P2W6, ALG10_USTMA;  
Q6CEA5, ALG10_YARLI;  P50076, ALG10_YEAST;  

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