ENZYME entry: EC 2.4.1.256
| Accepted Name |
|---|
| dolichyl-P-Glc:Glc2Man9GlcNAc2-PP-dolichol alpha-1,2-glucosyltransferase.
|
| Alternative Name(s) |
|---|
| Dol-P-Glc:Glc2Man9GlcNAc2-PP-Dol alpha1,2-glucosyltransferase. |
| Reaction catalysed |
|---|
| a dolichyl beta-D-glucosyl phosphate + alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol <=> a dolichyl phosphate + alpha-D-Glc-(1->2)-alpha-D-Glc-(1->3)-alpha-D-Glc-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+) |
| Comment(s) |
|---|
- This eukaryotic enzyme performs the final step in the synthesis of
the lipid-linked oligosaccharide, attaching D-glucose in an alpha-
1,2-linkage to the outermost D-glucose in the long branch.
- The lipid-linked oligosaccharide is involved in N-linked protein
glycosylation of selected asparagine residues of nascent polypeptide
chains in eukaryotic cells.
|
| Cross-references |
|---|
| BRENDA | 2.4.1.256 |
| EC2PDB | 2.4.1.256 |
| ExplorEnz | 2.4.1.256 |
| PRIAM enzyme-specific profiles | 2.4.1.256 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.4.1.256 |
| IUBMB Enzyme Nomenclature | 2.4.1.256 |
| IntEnz | 2.4.1.256 |
| MEDLINE | Find literature relating to 2.4.1.256 |
| MetaCyc | 2.4.1.256 |
| Rhea expert-curated reactions | 2.4.1.256 |
| UniProtKB/Swiss-Prot |
| Q5BKT4, AG10A_HUMAN; | Q5I7T1, AG10B_HUMAN; | Q3UGP8, AG10B_MOUSE; |
| O88788, AG10B_RAT; | Q8L638, ALG10_ARATH; | Q75AQ8, ALG10_ASHGO; |
| Q4X162, ALG10_ASPFU; | Q59YV2, ALG10_CANAL; | Q6FL34, ALG10_CANGA; |
| Q6BW42, ALG10_DEBHA; | Q8T8L8, ALG10_DROME; | Q5B0M8, ALG10_EMENI; |
| Q4HZE0, ALG10_GIBZE; | Q6CN27, ALG10_KLULA; | P0C147, ALG10_MAGO7; |
| Q7SA35, ALG10_NEUCR; | Q10254, ALG10_SCHPO; | Q4P2W6, ALG10_USTMA; |
| Q6CEA5, ALG10_YARLI; | P50076, ALG10_YEAST; |
|
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