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ENZYME

ENZYME entry: EC 2.4.1.258

PURL: https://purl.expasy.org/enzyme/EC/2.4.1.258
Accepted Name
dolichyl-P-Man:Man5GlcNAc2-PP-dolichol alpha-1,3-mannosyltransferase
Alternative Name(s)
Alg3 alpha-1,3-mannosyl transferase
Dol-P-Man:Man5GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase
Man5GlcNAc2-PP-Dol mannosyltransferase
Reaction catalysed
an alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl beta-D-mannosyl phosphate = an alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphospho-di-trans,poly-cis-dolichol + a di-trans,poly-cis-dolichyl phosphate + H(+)
Comment(s)
  • The formation of N-glycosidic linkages of glycoproteins involves the ordered assembly of the common Glc3Man9GlcNAc2 core-oligosaccharide on the lipid carrier dolichyl diphosphate.
  • Early mannosylation steps occur on the cytoplasmic side of the endoplasmic reticulum with GDP-Man as donor, the final reactions from Man5GlcNAc2-PP-dolichyl to Man9Glc-NAc2-PP-dolichyl on the lumenal side use dolichyl beta-D-mannosyl phosphate.
  • The first step of this assembly pathway on the luminal side of the endoplasmic reticulum is catalyzed by ALG3.
  • Formerly EC 2.4.1.130.
Cross-references
BRENDA2.4.1.258
EC2PDB2.4.1.258
ExplorEnz2.4.1.258
KEGG Ligand Database for Enzyme Nomenclature2.4.1.258
IUBMB Enzyme Nomenclature2.4.1.258
MEDLINEFind literature relating to 2.4.1.258
MetaCyc2.4.1.258
Rhea expert-curated reactions2.4.1.258
UniProtKB/Swiss-Prot
P82149, ALG3B_DROMEO82244, ALG3_ARATHA1CBE6, ALG3_ASPCL
Q4WVG2, ALG3_ASPFUA2RA94, ALG3_ASPNCQ2U6A4, ALG3_ASPOR
Q6FXS2, ALG3_CANGAP0CN93, ALG3_CRYNBP0CN92, ALG3_CRYNJ
Q6BYY8, ALG3_DEBHAQ55F69, ALG3_DICDIQ27333, ALG3_DROME
Q24332, ALG3_DROVIQ751K5, ALG3_EREGSQ92685, ALG3_HUMAN
Q6CMF1, ALG3_KLULAQ6DNA2, ALG3_KOMPGQ8K2A8, ALG3_MOUSE
A1DDZ3, ALG3_NEOFIQ9C1K8, ALG3_NEUCRQ0TVF9, ALG3_PHANO
A5DJQ5, ALG3_PICGUA3LTB7, ALG3_PICSTQ9Y7I4, ALG3_SCHPO
P38179, ALG3_YEAST

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