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ENZYME entry: EC 2.4.1.258

Accepted Name
dolichyl-P-Man:Man5GlcNAc2-PP-dolichol alpha-1,3-mannosyltransferase.
Alternative Name(s)
Alg3 alpha-1,3-mannosyl transferase.
Dol-P-Man:Man5GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase.
Man5GlcNAc2-PP-Dol mannosyltransferase.
Reaction catalysed
a dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol <=> a dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)
Comment(s)
  • The formation of N-glycosidic linkages of glycoproteins involves the ordered assembly of the common Glc3Man9GlcNAc2 core-oligosaccharide on the lipid carrier dolichyl diphosphate.
  • Early mannosylation steps occur on the cytoplasmic side of the endoplasmic reticulum with GDP-Man as donor, the final reactions from Man5GlcNAc2-PP-dolichyl to Man9Glc-NAc2-PP-dolichyl on the lumenal side use dolichyl beta-D-mannosyl phosphate.
  • The first step of this assembly pathway on the luminal side of the endoplasmic reticulum is catalyzed by ALG3.
  • Formerly EC 2.4.1.130.
Cross-references
BRENDA2.4.1.258
EC2PDB2.4.1.258
ExplorEnz2.4.1.258
PRIAM enzyme-specific profiles2.4.1.258
KEGG Ligand Database for Enzyme Nomenclature2.4.1.258
IUBMB Enzyme Nomenclature2.4.1.258
IntEnz2.4.1.258
MEDLINEFind literature relating to 2.4.1.258
MetaCyc2.4.1.258
Rhea expert-curated reactions2.4.1.258
UniProtKB/Swiss-Prot
O82244, ALG3_ARATH;  Q751K5, ALG3_ASHGO;  A1CBE6, ALG3_ASPCL;  
Q4WVG2, ALG3_ASPFU;  A2RA94, ALG3_ASPNC;  Q2U6A4, ALG3_ASPOR;  
Q6FXS2, ALG3_CANGA;  P0CN93, ALG3_CRYNB;  P0CN92, ALG3_CRYNJ;  
Q6BYY8, ALG3_DEBHA;  Q55F69, ALG3_DICDI;  Q92685, ALG3_HUMAN;  
Q6CMF1, ALG3_KLULA;  Q6DNA2, ALG3_KOMPG;  Q8K2A8, ALG3_MOUSE;  
A1DDZ3, ALG3_NEOFI;  Q9C1K8, ALG3_NEUCR;  Q0TVF9, ALG3_PHANO;  
A5DJQ5, ALG3_PICGU;  A3LTB7, ALG3_PICST;  Q9Y7I4, ALG3_SCHPO;  
P38179, ALG3_YEAST;  

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