ID   2.4.1.259
DE   dolichyl-P-Man:Man6GlcNAc2-PP-dolichol alpha-1,2-mannosyltransferase.
AN   Dol-P-Man:Man6GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase.
CA   a dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-
CA   (1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-
CA   Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol =
CA   a dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-
CA   (1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-
CA   Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+).
CC   -!- The formation of N-glycosidic linkages of glycoproteins involves the
CC       ordered assembly of the common Glc3Man9GlcNAc2 core-oligosaccharide
CC       on the lipid carrier dolichyl diphosphate.
CC   -!- Early mannosylation steps occur on the cytoplasmic side of the
CC       endoplasmic reticulum with GDP-Man as donor, the final reactions from
CC       Man5GlcNAc2-PP-dolichol to Man9Glc-NAc2-PP-dolichol on the lumenal
CC       side use dolichyl beta-D-mannosyl phosphate.
CC   -!- ALG9 mannosyltransferase catalyzes the addition of two different
CC       alpha-1,2-mannose residues - the addition of alpha-1,2-mannose to
CC       Man6GlcNAc2-PP-dolichol (EC 2.4.1.259) and the addition of alpha-1,2-
CC       mannose to Man8GlcNAc2-PP-dolichol (EC 2.4.1.261).
CC   -!- Formerly EC 2.4.1.130.
DR   Q9FZ49, ALG9_ARATH ;  P54002, ALG9_CAEEL ;  Q9H6U8, ALG9_HUMAN ;
DR   Q8VDI9, ALG9_MOUSE ;  Q9P7Q9, ALG9_SCHPO ;  P53868, ALG9_YEAST ;
//