ENZYME

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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 2.4.1.260

Accepted Name

Dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichol alpha-1,6-mannosyltransferase.

Alternative Name(s)

Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase.

Dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichyl alpha-6-mannosyltransferase.

Reaction catalysed

Dolichyl beta-D-mannosyl phosphate + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol <=> D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate

Comment(s)

The formation of N-glycosidic linkages of glycoproteins involves the ordered assembly of the common Glc(3)Man(9)GlcNAc(2) core- oligosaccharide on the lipid carrier dolichyl diphosphate.
Early mannosylation steps occur on the cytoplasmic side of the endoplasmic reticulum with GDP-Man as donor, the final reactions from Man(5)GlcNAc(2)-PP-dolichol to Man(9)Glc-NAc(2)-PP-dolichol on the lumenal side use dolichyl beta-D-mannosyl phosphate.
Formerly EC 2.4.1.130.

Cross-references

BRENDA

2.4.1.260

EC2PDB

2.4.1.260

ExplorEnz

2.4.1.260

PRIAM enzyme-specific profiles

2.4.1.260

KEGG Ligand Database for Enzyme Nomenclature

2.4.1.260

IUBMB Enzyme Nomenclature