ENZYME entry: EC 2.4.1.260
Accepted Name |
Dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichol alpha-1,6-mannosyltransferase.
|
Alternative Name(s) |
Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase. |
Dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichyl alpha-6-mannosyltransferase. |
Reaction catalysed |
Dolichyl beta-D-mannosyl phosphate + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol <=> D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate |
Comment(s) |
- The formation of N-glycosidic linkages of glycoproteins involves the
ordered assembly of the common Glc(3)Man(9)GlcNAc(2) core-
oligosaccharide on the lipid carrier dolichyl diphosphate.
- Early mannosylation steps occur on the cytoplasmic side of the
endoplasmic reticulum with GDP-Man as donor, the final reactions from
Man(5)GlcNAc(2)-PP-dolichol to Man(9)Glc-NAc(2)-PP-dolichol on the
lumenal side use dolichyl beta-D-mannosyl phosphate.
- Formerly EC 2.4.1.130.
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Cross-references |
BRENDA | 2.4.1.260 |
EC2PDB | 2.4.1.260 |
ExplorEnz | 2.4.1.260 |
PRIAM enzyme-specific profiles | 2.4.1.260 |
KEGG Ligand Database for Enzyme Nomenclature | 2.4.1.260 |
IUBMB Enzyme Nomenclature | 2.4.1.260 |
IntEnz | 2.4.1.260 |
MEDLINE | Find literature relating to 2.4.1.260 |
MetaCyc | 2.4.1.260 |
Rhea expert-curated reactions | 2.4.1.260 |
UniProtKB/Swiss-Prot |
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