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ENZYME entry: EC 2.4.1.260

Accepted Name
dolichyl-P-Man:Man7GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase.
Alternative Name(s)
dolichyl-P-Man:Man7GlcNAc2-PP-dolichyl alpha6-mannosyltransferase.
Dol-P-Man:Man7GlcNAc2-PP-Dol alpha-1,6-mannosyltransferase.
Reaction catalysed
a dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol <=> a dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+)
Comment(s)
  • The formation of N-glycosidic linkages of glycoproteins involves the ordered assembly of the common Glc3Man9GlcNAc2 core-oligosaccharide on the lipid carrier dolichyl diphosphate.
  • Early mannosylation steps occur on the cytoplasmic side of the endoplasmic reticulum with GDP-Man as donor, the final reactions from Man5GlcNAc2-PP-dolichol to Man9Glc-NAc2-PP-dolichol on the lumenal side use dolichyl beta-D-mannosyl phosphate.
  • Formerly EC 2.4.1.130.
Cross-references
BRENDA2.4.1.260
EC2PDB2.4.1.260
ExplorEnz2.4.1.260
PRIAM enzyme-specific profiles2.4.1.260
KEGG Ligand Database for Enzyme Nomenclature2.4.1.260
IUBMB Enzyme Nomenclature2.4.1.260
IntEnz2.4.1.260
MEDLINEFind literature relating to 2.4.1.260
MetaCyc2.4.1.260
Rhea expert-curated reactions2.4.1.260
UniProtKB/Swiss-Prot
A8MR93, ALG12_ARATH;  Q23361, ALG12_CAEEL;  Q9VH78, ALG12_DROME;  
Q9BV10, ALG12_HUMAN;  Q8VDB2, ALG12_MOUSE;  Q9USD4, ALG12_SCHPO;  
P53730, ALG12_YEAST;  

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