ENZYME entry: EC 2.4.1.260
| Accepted Name |
|---|
| Dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichol alpha-1,6-mannosyltransferase.
|
| Alternative Name(s) |
|---|
| Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase. |
| Dolichyl-P-Man:Man(7)GlcNAc(2)-PP-dolichyl alpha-6-mannosyltransferase. |
| Reaction catalysed |
|---|
| Dolichyl beta-D-mannosyl phosphate + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol <=> D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate |
| Comment(s) |
|---|
- The formation of N-glycosidic linkages of glycoproteins involves the
ordered assembly of the common Glc(3)Man(9)GlcNAc(2) core-
oligosaccharide on the lipid carrier dolichyl diphosphate.
- Early mannosylation steps occur on the cytoplasmic side of the
endoplasmic reticulum with GDP-Man as donor, the final reactions from
Man(5)GlcNAc(2)-PP-dolichol to Man(9)Glc-NAc(2)-PP-dolichol on the
lumenal side use dolichyl beta-D-mannosyl phosphate.
- Formerly EC 2.4.1.130.
|
| Cross-references |
|---|
| BRENDA | 2.4.1.260 |
| EC2PDB | 2.4.1.260 |
| ExplorEnz | 2.4.1.260 |
| PRIAM enzyme-specific profiles | 2.4.1.260 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.4.1.260 |
| IUBMB Enzyme Nomenclature | 2.4.1.260 |
| IntEnz | 2.4.1.260 |
| MEDLINE | Find literature relating to 2.4.1.260 |
| MetaCyc | 2.4.1.260 |
| UniProtKB/Swiss-Prot |
|
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