ENZYME entry: EC 2.4.1.260
| Accepted Name |
|---|
| dolichyl-P-Man:Man7GlcNAc2-PP-dolichol alpha-1,6-mannosyltransferase.
|
| Alternative Name(s) |
|---|
| dolichyl-P-Man:Man7GlcNAc2-PP-dolichyl alpha6-mannosyltransferase. |
| Dol-P-Man:Man7GlcNAc2-PP-Dol alpha-1,6-mannosyltransferase. |
| Reaction catalysed |
|---|
| a dolichyl beta-D-mannosyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol <=> a dolichyl phosphate + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-alpha-D-GlcNAc-diphosphodolichol + H(+) |
| Comment(s) |
|---|
- The formation of N-glycosidic linkages of glycoproteins involves the
ordered assembly of the common Glc3Man9GlcNAc2 core-oligosaccharide
on the lipid carrier dolichyl diphosphate.
- Early mannosylation steps occur on the cytoplasmic side of the
endoplasmic reticulum with GDP-Man as donor, the final reactions from
Man5GlcNAc2-PP-dolichol to Man9Glc-NAc2-PP-dolichol on the lumenal
side use dolichyl beta-D-mannosyl phosphate.
- Formerly EC 2.4.1.130.
|
| Cross-references |
|---|
| BRENDA | 2.4.1.260 |
| EC2PDB | 2.4.1.260 |
| ExplorEnz | 2.4.1.260 |
| PRIAM enzyme-specific profiles | 2.4.1.260 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.4.1.260 |
| IUBMB Enzyme Nomenclature | 2.4.1.260 |
| IntEnz | 2.4.1.260 |
| MEDLINE | Find literature relating to 2.4.1.260 |
| MetaCyc | 2.4.1.260 |
| Rhea expert-curated reactions | 2.4.1.260 |
| UniProtKB/Swiss-Prot |
|
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