ID   2.4.1.261
DE   Dolichyl-P-Man:Man(8)GlcNAc(2)-PP-dolichol alpha-1,2-mannosyltransferase.
AN   Dol-P-Man:Man(8)GlcNAc(2)-PP-Dol alpha-1,2-mannosyltransferase.
CA   Dolichyl beta-D-mannosyl phosphate + D-Man-alpha-(1->2)-D-Man-alpha-
CA   (1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-
CA   alpha-(1->6))-D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-
CA   D-GlcNAc-diphosphodolichol = D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-
CA   alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->2)-
CA   D-Man-alpha-(1->6))-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-
CA   (1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate.
CC   -!- The formation of N-glycosidic linkages of glycoproteins involves the
CC       ordered assembly of the common Glc(3)Man(9)GlcNAc(2) core-
CC       oligosaccharide on the lipid carrier dolichyl diphosphate.
CC   -!- Early mannosylation steps occur on the cytoplasmic side of the
CC       endoplasmic reticulum with GDP-Man as donor, the final reactions from
CC       Man(5)GlcNAc(2)-PP-Dol to Man(9)Glc-NAc(2)-PP-Dol on the lumenal side
CC       use dolichyl beta-D-mannosyl phosphate.
CC   -!- ALG9 mannosyltransferase catalyzes the addition of two different
CC       alpha-1,2-mannose residues - the addition of alpha-1,2-mannose to
CC       Man(6)GlcNAc(2)-PP-Dol (EC 2.4.1.259) and the addition of alpha-1,2-
CC       mannose to Man(8)GlcNAc(2)-PP-Dol (EC 2.4.1.261).
CC   -!- Formerly EC 2.4.1.130.
DR   Q9FZ49, ALG9_ARATH ;  P54002, ALG9_CAEEL ;  Q9H6U8, ALG9_HUMAN ;
DR   Q8VDI9, ALG9_MOUSE ;  Q9P7Q9, ALG9_SCHPO ;  P53868, ALG9_YEAST ;
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