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ENZYME entry: EC 2.4.1.283

Accepted Name
2-deoxystreptamine N-acetyl-D-glucosaminyltransferase.
Reaction catalysed
2-deoxystreptamine + UDP-N-acetyl-alpha-D-glucosamine <=> 2'-N-acetylparomamine + H(+) + UDP
Comment(s)
  • Involved in the biosynthetic pathways of several clinically important aminocyclitol antibiotics, including kanamycin, butirosin, neomycin and ribostamycin.
  • Unlike the enzyme from the bacterium Streptomyces kanamyceticus, which can also accept UDP-D-glucose (cf. EC 2.4.1.284), the enzyme from Bacillus circulans can only accept UDP-N-acetyl-alpha-D- glucosamine.
Cross-references
BRENDA2.4.1.283
EC2PDB2.4.1.283
ExplorEnz2.4.1.283
PRIAM enzyme-specific profiles2.4.1.283
KEGG Ligand Database for Enzyme Nomenclature2.4.1.283
IUBMB Enzyme Nomenclature2.4.1.283
IntEnz2.4.1.283
MEDLINEFind literature relating to 2.4.1.283
MetaCyc2.4.1.283
Rhea expert-curated reactions2.4.1.283
UniProtKB/Swiss-Prot
Q4H4F8, BTRM_NIACI;  Q65CC1, KANF_STRKN;  Q53U18, NEOD_STRFR;  

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