ENZYME entry: EC 2.4.1.283
Accepted Name |
2-deoxystreptamine N-acetyl-D-glucosaminyltransferase.
|
Reaction catalysed |
UDP-N-acetyl-alpha-D-glucosamine + 2-deoxystreptamine <=> UDP + 2'-N-acetylparomamine |
Comment(s) |
- Involved in the biosynthetic pathways of several clinically important
aminocyclitol antibiotics, including kanamycin, butirosin, neomycin
and ribostamycin.
- Unlike the enzyme from the bacterium Streptomyces kanamyceticus,
which can also accept UDP-D-glucose (cf. EC 2.4.1.284), the enzyme
from Bacillus circulans can only accept UDP-N-acetyl-alpha-D-
glucosamine.
|
Cross-references |
BRENDA | 2.4.1.283 |
EC2PDB | 2.4.1.283 |
ExplorEnz | 2.4.1.283 |
PRIAM enzyme-specific profiles | 2.4.1.283 |
KEGG Ligand Database for Enzyme Nomenclature | 2.4.1.283 |
IUBMB Enzyme Nomenclature | 2.4.1.283 |
IntEnz | 2.4.1.283 |
MEDLINE | Find literature relating to 2.4.1.283 |
MetaCyc | 2.4.1.283 |
Rhea expert-curated reactions | 2.4.1.283 |
UniProtKB/Swiss-Prot |
|
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