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ENZYME entry: EC 2.4.1.301

Accepted Name
2'-deamino-2'-hydroxyneamine 1-alpha-D-kanosaminyltransferase.
Reaction catalysed
  • UDP-alpha-D-kanosamine + 2'-deamino-2'-hydroxyneamine <=> UDP + kanamycin A
  • UDP-alpha-D-kanosamine + neamine <=> UDP + kanamycin B
  • UDP-alpha-D-kanosamine + paromamine <=> UDP + kanamycin C
  • UDP-alpha-D-kanosamine + 2'-deamino-2'-hydroxyparomamine <=> UDP + kanamycin X
Comment(s)
  • Involved in the biosynthetic pathway of kanamycins.
  • The enzyme characterized from the bacterium Streptomyces kanamyceticus can also accept UDP-alpha-D-glucose with lower efficiency.
Cross-references
BRENDA2.4.1.301
EC2PDB2.4.1.301
ExplorEnz2.4.1.301
PRIAM enzyme-specific profiles2.4.1.301
KEGG Ligand Database for Enzyme Nomenclature2.4.1.301
IUBMB Enzyme Nomenclature2.4.1.301
IntEnz2.4.1.301
MEDLINEFind literature relating to 2.4.1.301
MetaCyc2.4.1.301
Rhea expert-curated reactions2.4.1.301
UniProtKB/Swiss-Prot
Q65CC7, KANE_STRKN

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