ENZYME entry: EC 2.4.1.313

Accepted Name

Protein O-mannose beta-1,3-N-acetylgalactosaminyltransferase.

Reaction catalysed

UDP-N-acetyl-alpha-D-galactosamine + 3-O-(N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-threonyl-[protein] <=> UDP + 3-O-(N-acetyl-beta-D-galactosaminyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-threonyl-[protein]

Comment(s)

The human protein is specific for UDP-N-acetyl-alpha-D-galactosamine as donor.
The enzyme is involved in the formation of a phosphorylated trisaccharide on a threonine residue of alpha-dystroglycan, an extracellular peripheral glycoprotein that acts as a receptor for extracellular matrix proteins containing laminin-G domains.

Cross-references

BRENDA

2.4.1.313

EC2PDB

2.4.1.313

ExplorEnz

2.4.1.313

PRIAM enzyme-specific profiles

2.4.1.313

KEGG Ligand Database for Enzyme Nomenclature

2.4.1.313

IUBMB Enzyme Nomenclature

2.4.1.313

IntEnz

2.4.1.313

MEDLINE

Find literature relating to 2.4.1.313

MetaCyc

2.4.1.313

UniProtKB/Swiss-Prot

Q502B3, B3GL2_DANRE;	Q8NCR0, B3GL2_HUMAN;	Q8BG28, B3GL2_MOUSE;
Q6NRQ1, B3GL2_XENLA;	Q5M900, B3GL2_XENTR;

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.

All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.-.-
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