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ENZYME entry: EC 2.4.1.313

Accepted Name
protein O-mannose beta-1,3-N-acetylgalactosaminyltransferase.
Reaction catalysed
3-O-(N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine <=> 3-O-[beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-alpha-D-Man]-L-Thr-[protein] + H(+) + UDP
Comment(s)
  • The human protein is specific for UDP-N-acetyl-alpha-D-galactosamine as donor.
  • The enzyme is involved in the formation of a phosphorylated trisaccharide on a threonine residue of alpha-dystroglycan, an extracellular peripheral glycoprotein that acts as a receptor for extracellular matrix proteins containing laminin-G domains.
Cross-references
BRENDA2.4.1.313
EC2PDB2.4.1.313
ExplorEnz2.4.1.313
PRIAM enzyme-specific profiles2.4.1.313
KEGG Ligand Database for Enzyme Nomenclature2.4.1.313
IUBMB Enzyme Nomenclature2.4.1.313
IntEnz2.4.1.313
MEDLINEFind literature relating to 2.4.1.313
MetaCyc2.4.1.313
Rhea expert-curated reactions2.4.1.313
UniProtKB/Swiss-Prot
Q502B3, B3GL2_DANRE;  Q8NCR0, B3GL2_HUMAN;  Q8BG28, B3GL2_MOUSE;  
Q6NRQ1, B3GL2_XENLA;  Q5M900, B3GL2_XENTR;  

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