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ENZYME entry: EC 2.4.1.313
Accepted Name |
protein O-mannose beta-1,3-N-acetylgalactosaminyltransferase.
|
Reaction catalysed |
3-O-(N-acetyl-beta-D-glucosaminyl-(1->4)-alpha-D-mannosyl)-L-threonyl-[protein] + UDP-N-acetyl-alpha-D-galactosamine <=> 3-O-[beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-alpha-D-Man]-L-Thr-[protein] + H(+) + UDP |
Comment(s) |
- The human protein is specific for UDP-N-acetyl-alpha-D-galactosamine
as donor.
- The enzyme is involved in the formation of a phosphorylated
trisaccharide on a threonine residue of alpha-dystroglycan,
an extracellular peripheral glycoprotein that acts as a receptor for
extracellular matrix proteins containing laminin-G domains.
|
Cross-references |
BRENDA | 2.4.1.313 |
EC2PDB | 2.4.1.313 |
ExplorEnz | 2.4.1.313 |
PRIAM enzyme-specific profiles | 2.4.1.313 |
KEGG Ligand Database for Enzyme Nomenclature | 2.4.1.313 |
IUBMB Enzyme Nomenclature | 2.4.1.313 |
IntEnz | 2.4.1.313 |
MEDLINE | Find literature relating to 2.4.1.313 |
MetaCyc | 2.4.1.313 |
Rhea expert-curated reactions | 2.4.1.313 |
UniProtKB/Swiss-Prot |
|
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ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 2.4.1.-
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