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ENZYME entry: EC 2.4.1.370

Accepted Name
Inositol phosphorylceramide mannosyltransferase.
Reaction catalysed
GDP-alpha-D-mannose + a (4R)-4-hydroxy-N-((2R)-2-hydroxy-very-long-chain-acyl)-1-O-((1D-myo-inositol-1-O-yl)hydroxyphosphoryl)sphinganine <=> a (4R)-4-hydroxy-N-((2R)-2-hydroxy-very-long-chain-acyl)-1-O-((6-O-(alpha-D-mannosyl)-1D-myo-inositol-1-O-yl)hydroxyphosphoryl)sphinganine + GDP
Comment(s)
  • The simplest complex sphingolipid of yeast, inositol-phospho-alpha- hydroxyphytoceramide (IPC), is usually mannosylated to yield mannosyl-inositol-phospho-alpha hydroxyphytoceramide (MIPC).
  • The enzyme is located in the Golgi apparatus, and utilizes GDP-alpha- D-mannose as the mannosyl group donor.
  • It consists of a catalytic subunit (SUR1 or CSH1) and a regulatory subunit (CSG2).
Cross-references
BRENDA2.4.1.370
EC2PDB2.4.1.370
ExplorEnz2.4.1.370
PRIAM enzyme-specific profiles2.4.1.370
KEGG Ligand Database for Enzyme Nomenclature2.4.1.370
IUBMB Enzyme Nomenclature2.4.1.370
IntEnz2.4.1.370
MEDLINEFind literature relating to 2.4.1.370
MetaCyc2.4.1.370
Rhea expert-curated reactions2.4.1.370
UniProtKB/Swiss-Prot
P38287, CSH1_YEAST;  P33300, SUR1_YEAST;  

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