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ENZYME entry: EC 2.4.1.371

Accepted Name
Polymannosyl GlcNAc-diphospho-ditrans,octacis-undecaprenol 2,3-alpha- mannosylpolymerase.
Reaction catalysed
  • 2 GDP-alpha-D-mannose + (alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2))(n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-diphospho-ditrans,octacis-undecaprenol <=> 2 GDP + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-(alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2))(n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-diphospho-ditrans,octacis-undecaprenol
  • 2 GDP-alpha-D-mannose + alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-(alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2))(n)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-diphospho-ditrans,octacis-undecaprenol <=> 2 GDP + (alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->2)-alpha-D-Man-(1->2))(n+1)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-Man-(1->3)-alpha-D-GlcNAc-diphospho-ditrans,octacis-undecaprenol
Comment(s)
  • The enzyme is involved in the biosynthesis of polymannose O-polysaccharide in the outer leaflet of the membrane of Escherichia coli serotype O9a.
  • The enzymes consists of two domains that are responsible for the 1->2 and 1->3 linkages, respectively.
Cross-references
BRENDA2.4.1.371
EC2PDB2.4.1.371
ExplorEnz2.4.1.371
PRIAM enzyme-specific profiles2.4.1.371
KEGG Ligand Database for Enzyme Nomenclature2.4.1.371
IUBMB Enzyme Nomenclature2.4.1.371
IntEnz2.4.1.371
MEDLINEFind literature relating to 2.4.1.371
MetaCyc2.4.1.371
Rhea expert-curated reactions2.4.1.371

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