ID   2.4.1.376
DE   EGF-domain serine glucosyltransferase.
CA   L-seryl-[EGF-like domain protein] + UDP-alpha-D-glucose = 3-O-(beta-D-
CA   glucosyl)-L-seryl-[EGF-like domain protein] + H(+) + UDP.
CC   -!- The enzyme, found in animals and insects, is involved in the
CC       biosynthesis of the alpha-D-xylosyl-(1->3)-alpha-D-xylosyl-(1->3)-
CC       beta-D-glucosyl trisaccharide on epidermal growth factor-like (EGF-
CC       like) domains.
CC   -!- Glycosylation takes place at the serine in the C-X-S-X-P-C motif.
CC   -!- The enzyme is bifunctional also being active with UDP-alpha-xylose as
CC       donor (EC 2.4.2.63).
CC   -!- When present on Notch proteins, the trisaccharide functions as a
CC       modulator of the signaling activity of this protein.
DR   Q5E9Q1, PGLT1_BOVIN;  Q8NBL1, PGLT1_HUMAN;  Q8BYB9, PGLT1_MOUSE;
DR   G3V9D0, PGLT1_RAT  ;
//