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ENZYME entry: EC 2.4.1.47

Accepted Name
N-acylsphingosine galactosyltransferase.
Alternative Name(s)
2-hydroxyacylsphingosine 1-beta-galactosyltransferase.
Reaction catalysed
UDP-alpha-D-galactose + N-acylsphingosine <=> UDP + beta-D-galactosylceramide
Comment(s)
  • This membrane-bound, endoplasmic reticulum-located enzyme catalyzes the last step in the synthesis of galactocerebrosides, which are abundant sphingolipids of the myelin membrane of the central nervous system and peripheral nervous system.
  • It has a strong preference for ceramides that contain hydroxylated fatty acids.
  • Formerly EC 2.4.1.45.
Cross-references
BRENDA2.4.1.47
EC2PDB2.4.1.47
ExplorEnz2.4.1.47
PRIAM enzyme-specific profiles2.4.1.47
KEGG Ligand Database for Enzyme Nomenclature2.4.1.47
IUBMB Enzyme Nomenclature2.4.1.47
IntEnz2.4.1.47
MEDLINEFind literature relating to 2.4.1.47
MetaCyc2.4.1.47
Rhea expert-curated reactions2.4.1.47
UniProtKB/Swiss-Prot
Q16880, CGT_HUMAN;  Q64676, CGT_MOUSE;  Q09426, CGT_RAT;  

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