ENZYME entry: EC 2.4.1.47
| Accepted Name |
|---|
| N-acylsphingosine galactosyltransferase.
|
| Alternative Name(s) |
|---|
| 2-hydroxyacylsphingosine 1-beta-galactosyltransferase. |
| Reaction catalysed |
|---|
| UDP-alpha-D-galactose + N-acylsphingosine <=> UDP + beta-D-galactosylceramide |
| Comment(s) |
|---|
- This membrane-bound, endoplasmic reticulum-located enzyme catalyzes
the last step in the synthesis of galactocerebrosides, which are
abundant sphingolipids of the myelin membrane of the central nervous
system and peripheral nervous system.
- It has a strong preference for ceramides that contain hydroxylated
fatty acids.
- Formerly EC 2.4.1.45.
|
| Cross-references |
|---|
| BRENDA | 2.4.1.47 |
| EC2PDB | 2.4.1.47 |
| ExplorEnz | 2.4.1.47 |
| PRIAM enzyme-specific profiles | 2.4.1.47 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.4.1.47 |
| IUBMB Enzyme Nomenclature | 2.4.1.47 |
| IntEnz | 2.4.1.47 |
| MEDLINE | Find literature relating to 2.4.1.47 |
| MetaCyc | 2.4.1.47 |
| UniProtKB/Swiss-Prot |
|
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