ENZYME entry: EC 2.4.1.47
Accepted Name |
N-acylsphingosine galactosyltransferase.
|
Alternative Name(s) |
2-hydroxyacylsphingosine 1-beta-galactosyltransferase. |
Reaction catalysed |
an N-acylsphing-4-enine + UDP-alpha-D-galactose <=> a beta-D-galactosyl-(1<->1')-N-acylsphing-4-enine + H(+) + UDP |
Comment(s) |
- This membrane-bound, endoplasmic reticulum-located enzyme catalyzes
the last step in the synthesis of galactocerebrosides, which are
abundant sphingolipids of the myelin membrane of the central nervous
system and peripheral nervous system.
- It has a strong preference for ceramides that contain hydroxylated
fatty acids.
- Formerly EC 2.4.1.45.
|
Cross-references |
BRENDA | 2.4.1.47 |
EC2PDB | 2.4.1.47 |
ExplorEnz | 2.4.1.47 |
PRIAM enzyme-specific profiles | 2.4.1.47 |
KEGG Ligand Database for Enzyme Nomenclature | 2.4.1.47 |
IUBMB Enzyme Nomenclature | 2.4.1.47 |
IntEnz | 2.4.1.47 |
MEDLINE | Find literature relating to 2.4.1.47 |
MetaCyc | 2.4.1.47 |
Rhea expert-curated reactions | 2.4.1.47 |
UniProtKB/Swiss-Prot |
|
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