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ENZYME entry: EC 2.4.1.70

Accepted Name
poly(ribitol-phosphate) alpha-N-acetylglucosaminyltransferase.
Alternative Name(s)
poly(ribitol-phosphate) N-acetylglucosaminyltransferase.
UDP acetylglucosamine-poly(ribitol phosphate) acetylglucosaminyltransferase.
Reaction catalysed
4-O-[(D-ribitylphospho)(n)-di{(2R)-glycerylphospho}]-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n UDP-N-acetyl-alpha-D-glucosamine <=> 4-O-([2-N-acetyl-alpha-D-glucosaminyl-1-D-ribitylphospho](n)-di{[2R]-1-glycerylphospho})-N-acetyl-beta-D-mannosaminyl-(1->4)-N-acetyl-alpha-D-glucosaminyl di-trans,octa-cis-undecaprenyl diphosphate + n H(+) + n UDP
Comment(s)
  • Involved in the biosynthesis of poly(ribitol phosphate) teichoic acids in the cell wall of the bacterium Staphylococcus aureus.
  • This enzyme adds an N-acetyl-alpha-D-glucosamine to the hydroxyl group at the 2 position of the ribitol phosphate units.
  • Cf. EC 2.4.1.355.
Cross-references
BRENDA2.4.1.70
EC2PDB2.4.1.70
ExplorEnz2.4.1.70
PRIAM enzyme-specific profiles2.4.1.70
KEGG Ligand Database for Enzyme Nomenclature2.4.1.70
IUBMB Enzyme Nomenclature2.4.1.70
IntEnz2.4.1.70
MEDLINEFind literature relating to 2.4.1.70
MetaCyc2.4.1.70
Rhea expert-curated reactions2.4.1.70
UniProtKB/Swiss-Prot
A0A0H2WWV6, TARM_STAAC

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