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ENZYME

ENZYME entry: EC 2.4.1.86

Accepted Name
N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase
Alternative Name(s)
glucosaminylgalactosylglucosylceramide 4-beta-galactosyltransferase
glucosaminylgalactosylglucosylceramide beta-galactosyltransferase
lactotriaosylceramide 4-beta-galactosyltransferase
paragloboside synthase
Reaction catalysed
an N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D-galactose <=> a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP
Comment(s)
  • The enzyme transfers galactose from UDP-alpha-D-galactose to the 3-position of substrates with a non-reducing terminal N-acetyl-beta- D-glucosamine (beta-GlcNAc) residue.
  • It can act on both glycolipids and glycoproteins, generating a structure known as the type 1 histo-blood group antigen precursor.
Cross-references
BRENDA2.4.1.86
EC2PDB2.4.1.86
ExplorEnz2.4.1.86
PRIAM enzyme-specific profiles2.4.1.86
KEGG Ligand Database for Enzyme Nomenclature2.4.1.86
IUBMB Enzyme Nomenclature2.4.1.86
IntEnz2.4.1.86
MEDLINEFind literature relating to 2.4.1.86
MetaCyc2.4.1.86
Rhea expert-curated reactions2.4.1.86
UniProtKB/Swiss-Prot
Q7JK24, B3GT1_GORGOQ9Y5Z6, B3GT1_HUMANO54904, B3GT1_MOUSE
Q7JK25, B3GT1_PANPAQ7JK26, B3GT1_PANTRQ9MYM7, B3GT1_PONPY
O43825, B3GT2_HUMANO54905, B3GT2_MOUSEQ5R5Y3, B3GT2_PONAB

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.1.-
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