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ENZYME entry: EC 2.4.1.86

Accepted Name
N-acetyl-beta-D-glucosaminide beta-(1,3)-galactosyltransferase.
Alternative Name(s)
glucosaminylgalactosylglucosylceramide 4-beta-galactosyltransferase.
glucosaminylgalactosylglucosylceramide beta-galactosyltransferase.
lactotriaosylceramide 4-beta-galactosyltransferase.
paragloboside synthase.
Reaction catalysed
an N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D-galactose <=> a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-glucosaminyl derivative + H(+) + UDP
Comment(s)
  • The enzyme transfers galactose from UDP-alpha-D-galactose to the 3-position of substrates with a non-reducing terminal N-acetyl-beta- D-glucosamine (beta-GlcNAc) residue.
  • It can act on both glycolipids and glycoproteins, generating a structure known as the type 1 histo-blood group antigen precursor.
Cross-references
BRENDA2.4.1.86
EC2PDB2.4.1.86
ExplorEnz2.4.1.86
PRIAM enzyme-specific profiles2.4.1.86
KEGG Ligand Database for Enzyme Nomenclature2.4.1.86
IUBMB Enzyme Nomenclature2.4.1.86
IntEnz2.4.1.86
MEDLINEFind literature relating to 2.4.1.86
MetaCyc2.4.1.86
Rhea expert-curated reactions2.4.1.86
UniProtKB/Swiss-Prot
Q7JK24, B3GT1_GORGO;  Q9Y5Z6, B3GT1_HUMAN;  O54904, B3GT1_MOUSE;  
Q7JK25, B3GT1_PANPA;  Q7JK26, B3GT1_PANTR;  Q9MYM7, B3GT1_PONPY;  
O43825, B3GT2_HUMAN;  O54905, B3GT2_MOUSE;  Q5R5Y3, B3GT2_PONAB;  

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