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ENZYME

ENZYME entry: EC 2.4.1.87

PURL: https://purl.expasy.org/enzyme/EC/2.4.1.87
Accepted Name
N-acetyllactosaminide 3-alpha-galactosyltransferase
Alternative Name(s)
alpha-galactosyltransferase
beta-D-galactosyl-N-acetylglucosaminylglycopeptide alpha-1,3- galactosyltransferase
galactosyltransferase
glucosaminylglycopeptide alpha-1,3-galactosyltransferase
N-acetyllactosaminide alpha-1,3-galactosyltransferase
UDP-Gal:Gal-beta-1->4GlcNAc-R alpha-1->3-galactosyltransferase
UDP-Gal:N-acetyllactosaminide alpha-1,3-D-galactosyltransferase
UDPgalactose:beta-D-galactosyl-beta-1,4-N-acetyl-D-glucosaminyl- glycopeptide alpha-1,3-D-galactosyltransferase
UDP-galactose-acetyllactosamine alpha-D-galactosyltransferase
uridine diphosphogalactose-acetyllactosamine alpha1->3-galactosyltransferase
uridine diphosphogalactose-acetyllactosamine galactosyltransferase
uridine diphosphogalactose-galactosylacetylglucosaminylgalactosyl- glucosylceramide galactosyltransferase
Reaction catalysed
a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP-alpha-D-galactose = an alpha-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + UDP + H(+)
Comment(s)
  • Acts on beta-galactosyl-1,4-N-acetylglucosaminyl termini on asialo- alpha1-acid glycoprotein and N-acetyllactosamine (beta-D-galactosyl- 1,4-N-acetyl-beta-D-glucosamine), but not on 2'-fucosylated-N- acetyllactosamine.
  • The non-reducing terminal N-acetyllactosamine residues of glycoproteins can also act as acceptor.
  • Formerly EC 2.4.1.124 and EC 2.4.1.151.
Cross-references
BRENDA2.4.1.87
EC2PDB2.4.1.87
ExplorEnz2.4.1.87
KEGG Ligand Database for Enzyme Nomenclature2.4.1.87
IUBMB Enzyme Nomenclature2.4.1.87
MEDLINEFind literature relating to 2.4.1.87
MetaCyc2.4.1.87
Rhea expert-curated reactions2.4.1.87
UniProtKB/Swiss-Prot
U3KPV4, A3LT2_HUMANQ3V1N9, A3LT2_MOUSEA0A4Z3, A3LT2_RAT
A1YGR5, GGTA1_ALOCAP14769, GGTA1_BOVINQ8SQ20, GGTA1_CALJA
Q8HY56, GGTA1_FELCAQ8HYB2, GGTA1_LEMCAA1YGR6, GGTA1_LORTA
P23336, GGTA1_MOUSEP50127, GGTA1_PIGQ3L7M0, GGTA1_RAT
Q8SPR2, GGTA1_SAPAPA2AUQ7, GTA1L_MOUSEG3V9Q9, GTA1L_RAT

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-