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ENZYME

ENZYME entry: EC 2.4.1.92

PURL: https://purl.expasy.org/enzyme/EC/2.4.1.92
Accepted Name
(N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase
Alternative Name(s)
asialo-GM2 synthase
beta-1,4N-aetylgalactosaminyltransferase
GalNAc-T
ganglioside GM2 synthase
ganglioside GM3 acetylgalactosaminyltransferase
GM2/GD2-synthase
GM2 synthase
UDP acetylgalactosamine-(N-acetylneuraminyl)-D-galactosyl-D- glucosylceramide acetylgalactosaminyltransferase
UDP-N-acetylgalactosamine GM3 N-acetylgalactosaminyltransferase
uridine diphosphoacetylgalactosamine- acetylneuraminylgalactosylglucosylceramide acetylgalactosaminyltransferase
uridine diphosphoacetylgalactosamine-ganglioside GM3 acetylgalactosaminyltransferase
uridine diphosphoacetylgalactosamine-hematoside acetylgalactosaminyltransferase
Reaction catalysed
a ganglioside GM3 (d18:1(4E)) + UDP-N-acetyl-alpha-D-galactosamine = a ganglioside GM2 (d18:1(4E)) + UDP + H(+)
Comment(s)
  • Catalyzes the formation of the gangliosides (i.e. sialic-acid- containing glycosphingolipids) GM2, GD2 and SM2 from GM3, GD3 and SM3, respectively.
  • Asialo-GM3 and lactosylceramide are also substrates, but glycoproteins and oligosaccharides are not substrates.
Cross-references
BRENDA2.4.1.92
EC2PDB2.4.1.92
ExplorEnz2.4.1.92
KEGG Ligand Database for Enzyme Nomenclature2.4.1.92
IUBMB Enzyme Nomenclature2.4.1.92
MEDLINEFind literature relating to 2.4.1.92
MetaCyc2.4.1.92
Rhea expert-curated reactions2.4.1.92
UniProtKB/Swiss-Prot
Q00973, B4GN1_HUMANQ09200, B4GN1_MOUSEQ10468, B4GN1_RAT

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-