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ENZYME

ENZYME entry: EC 2.4.2.19

Accepted Name
nicotinate-nucleotide diphosphorylase (carboxylating)
Alternative Name(s)
nicotinate-nucleotide pyrophosphorylase (carboxylating)
quinolinate phosphoribosyltransferase (decarboxylating)
Reaction catalysed
CO2 + diphosphate + nicotinate beta-D-ribonucleotide <=> 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+) + quinolinate
Comment(s)
  • The reaction is catalyzed in the opposite direction.
  • Since quinolinate is synthesized from L-tryptophan in eukaryotes, but from L-aspartate in some prokaryotes, this is the first NAD+ biosynthesis enzyme shared by both eukaryotes and prokaryotes.
Cross-references
BRENDA2.4.2.19
EC2PDB2.4.2.19
ExplorEnz2.4.2.19
PRIAM enzyme-specific profiles2.4.2.19
KEGG Ligand Database for Enzyme Nomenclature2.4.2.19
IUBMB Enzyme Nomenclature2.4.2.19
IntEnz2.4.2.19
MEDLINEFind literature relating to 2.4.2.19
MetaCyc2.4.2.19
Rhea expert-curated reactions2.4.2.19
UniProtKB/Swiss-Prot
Q9ZU32, NADC_ARATHO28439, NADC_ARCFUP39666, NADC_BACSU
Q3T063, NADC_BOVINQ75JX0, NADC_DICDIP30011, NADC_ECOLI
Q9ZJN2, NADC_HELPJO25909, NADC_HELPYQ15274, NADC_HUMAN
Q57916, NADC_METJAO27860, NADC_METTHQ91X91, NADC_MOUSE
P46714, NADC_MYCLEP9WJJ6, NADC_MYCTOP9WJJ7, NADC_MYCTU
A7SG73, NADC_NEMVEQ0IZS0, NADC_ORYSJI3LK75, NADC_PIG
P30819, NADC_PSEAEQ5I0M2, NADC_RATP77938, NADC_RHORU
P30012, NADC_SALTYP74301, NADC_SYNY3P43619, NADC_YEAST
A0A1S4D475, QPT1A_TOBACA0A1S4DF18, QPT1B_TOBACB2RFT0, QPT1_NICGL
A0A1S4DFD3, QPT2A_TOBACA0A1S4CL59, QPT2B_TOBACB2RFS9, QPT2_NICGL

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.-.-
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