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ENZYME

ENZYME entry: EC 2.4.2.2

Accepted Name
pyrimidine-nucleoside phosphorylase
Alternative Name(s)
Py-NPase
Reaction catalysed
  • phosphate + uridine <=> alpha-D-ribose 1-phosphate + uracil
  • cytidine + phosphate <=> alpha-D-ribose 1-phosphate + cytosine
  • 2'-deoxyuridine + phosphate <=> 2-deoxy-alpha-D-ribose 1-phosphate + uracil
  • phosphate + thymidine <=> 2-deoxy-alpha-D-ribose 1-phosphate + thymine
Comment(s)
  • Unlike EC 2.4.2.3 and EC 2.4.2.4, this enzyme can accept both the ribonucleoside uridine and the 2'-deoxyribonucleosides 2'-deoxyuridine and thymidine.
  • The reaction is reversible, and the enzyme does not distinguish between alpha-D-ribose 1-phosphate and 2-deoxy-alpha-D-ribose 1-phosphate in the synthetic direction.
  • Formerly EC 2.4.2.23.
Cross-references
BRENDA2.4.2.2
EC2PDB2.4.2.2
ExplorEnz2.4.2.2
PRIAM enzyme-specific profiles2.4.2.2
KEGG Ligand Database for Enzyme Nomenclature2.4.2.2
IUBMB Enzyme Nomenclature2.4.2.2
IntEnz2.4.2.2
MEDLINEFind literature relating to 2.4.2.2
MetaCyc2.4.2.2
Rhea expert-curated reactions2.4.2.2
UniProtKB/Swiss-Prot
P39142, PDP_BACSUP77836, PDP_GEOSEQ2FEZ3, PDP_STAA3
Q2FWC1, PDP_STAA8Q2YUL7, PDP_STAABQ5HE64, PDP_STAAC
Q99SC3, PDP_STAAMQ7A4D0, PDP_STAANQ6GET9, PDP_STAAR
Q6G7H4, PDP_STAASQ8NVF6, PDP_STAAWQ5HM85, PDP_STAEQ
Q8CNH8, PDP_STAESQ4L818, PDP_STAHJQ4FVM5, PPNP1_PSYA2
Q1QEQ5, PPNP1_PSYCKQ4FTI5, PPNP2_PSYA2Q1QCI5, PPNP2_PSYCK
A1TNA3, PPNP_ACIACQ6FF51, PPNP_ACIADB7H1G4, PPNP_ACIB3
B2I2L6, PPNP_ACIBCB0VLV6, PPNP_ACIBSA3M1J3, PPNP_ACIBT
B0VE72, PPNP_ACIBYB9MBJ1, PPNP_ACIETA1W9F8, PPNP_ACISJ
A0KK62, PPNP_AERHHA4SMV5, PPNP_AERS4Q21UZ9, PPNP_ALBFT
Q0VL74, PPNP_ALCBSQ5E022, PPNP_ALIF1B5ETU8, PPNP_ALIFM
B6ERS6, PPNP_ALISLA7HG34, PPNP_ANADFQ5P0Z5, PPNP_AROAE
A1K7J6, PPNP_AZOSBC1DM65, PPNP_AZOVDB1YX25, PPNP_BURA4
A0B0V3, PPNP_BURCHB4ELA5, PPNP_BURCJQ0B8K0, PPNP_BURCM
Q397E7, PPNP_BURL3A9AR64, PPNP_BURM1B1K3J6, PPNP_BURO0
Q1BNU0, PPNP_BURO1A4JP25, PPNP_BURVGB3PHG9, PPNP_CELJU
Q3ATW8, PPNP_CHLCHB5E8R2, PPNP_CITBBA8AK73, PPNP_CITK8
A6LUD4, PPNP_CLOB8Q186L5, PPNP_CLOD6Q47UP5, PPNP_COLP3
A7MLW9, PPNP_CROS8Q1LJA2, PPNP_CUPMCQ0K784, PPNP_CUPNH
Q46XL0, PPNP_CUPPJB3R6D5, PPNP_CUPTRQ47BM2, PPNP_DECAR
A9BM59, PPNP_DELASA7ZIE0, PPNP_ECO24B7UJL5, PPNP_ECO27
B7MD50, PPNP_ECO45B7L546, PPNP_ECO55P0C039, PPNP_ECO57
B5Z2U3, PPNP_ECO5EB7NJB1, PPNP_ECO7IB7MPF2, PPNP_ECO81
B7M3N0, PPNP_ECO8AC4ZTF0, PPNP_ECOBWB1XEY0, PPNP_ECODH
A1A863, PPNP_ECOK1Q0TKP9, PPNP_ECOL5P0C038, PPNP_ECOL6
B1J057, PPNP_ECOLCP0C037, PPNP_ECOLIB7N8U3, PPNP_ECOLU
B6HZJ1, PPNP_ECOSEB1LIS5, PPNP_ECOSMQ1RFF2, PPNP_ECOUT
C5BHN8, PPNP_EDWI9A4W766, PPNP_ENT38B2VIS3, PPNP_ERWT9
B7LMJ4, PPNP_ESCF3B9M2Y9, PPNP_GEODFQ39UR5, PPNP_GEOMG
Q74DI8, PPNP_GEOSLC6E375, PPNP_GEOSMA5G3P2, PPNP_GEOUR
Q2SC73, PPNP_HAHCHA4G3H0, PPNP_HERARQ31FE7, PPNP_HYDCU
A6SW89, PPNP_JANMAB5Y110, PPNP_KLEP3A6T5B6, PPNP_KLEP7
C1D7Z6, PPNP_LARHHQ04PM6, PPNP_LEPBJQ055P9, PPNP_LEPBL
B1Y2G9, PPNP_LEPCPQ72NZ6, PPNP_LEPICQ8F7H3, PPNP_LEPIN
A0LAN9, PPNP_MAGMMA1U4L8, PPNP_MARN8Q609M6, PPNP_METCA
Q1H0L2, PPNP_METFKQ5YZH4, PPNP_NOCFAB2T9B1, PPNP_PARPJ
Q13FB9, PPNP_PARXLQ6D871, PPNP_PECASC6DB05, PPNP_PECCP
A1AUE4, PPNP_PELPDQ6LLX8, PPNP_PHOPRA1VL72, PPNP_POLNA
Q12D54, PPNP_POLSJQ48KQ0, PPNP_PSE14Q15VL9, PPNP_PSEA6
A6V7S3, PPNP_PSEA7B7UVE8, PPNP_PSEA8Q02K58, PPNP_PSEAB
Q9I3E3, PPNP_PSEAEQ1ICG2, PPNP_PSEE4Q4K8Z0, PPNP_PSEF5
C3K0G3, PPNP_PSEFSA4XVA3, PPNP_PSEMYA5W0W6, PPNP_PSEP1
Q3K965, PPNP_PSEPFB0KPU9, PPNP_PSEPGQ88F51, PPNP_PSEPK
B1JBX3, PPNP_PSEPWQ884R6, PPNP_PSESMQ3IDP9, PPNP_PSET1
Q4ZVE4, PPNP_PSEU2A1SZG8, PPNP_PSYINB2UBA2, PPNP_RALPJ
Q8XWC2, PPNP_RALSOQ7USA1, PPNP_RHOBAQ21KC3, PPNP_SACD2
B5EWS3, PPNP_SALA4A9MMR9, PPNP_SALARQ57SH3, PPNP_SALCH
B5FKP6, PPNP_SALDCB5QTE0, PPNP_SALEPB5R5Y2, PPNP_SALG2
B4T8N0, PPNP_SALHSB4SW31, PPNP_SALNSQ5PFU0, PPNP_SALPA
A9MX47, PPNP_SALPBC0Q7R4, PPNP_SALPCB5BDE2, PPNP_SALPK
B4TZG4, PPNP_SALSVQ8Z8Y9, PPNP_SALTIQ8ZRE7, PPNP_SALTY
A8GAJ0, PPNP_SERP5A1SB70, PPNP_SHEAMB8E465, PPNP_SHEB2
A3CZ93, PPNP_SHEB5A6WHZ7, PPNP_SHEB8A9KX59, PPNP_SHEB9
Q12P69, PPNP_SHEDOQ088X9, PPNP_SHEFNB0TV29, PPNP_SHEHH
Q8E927, PPNP_SHEONA8H8U2, PPNP_SHEPAA4Y2C8, PPNP_SHEPC
A0KRT7, PPNP_SHESAQ0HNM4, PPNP_SHESMQ0HQ66, PPNP_SHESR
A1REI6, PPNP_SHESWB2U3Z3, PPNP_SHIB3Q325K7, PPNP_SHIBS
Q32JE0, PPNP_SHIDSQ0T7J7, PPNP_SHIF8P0C040, PPNP_SHIFL
Q3Z519, PPNP_SHISSA9FFI1, PPNP_SORC5Q30NQ5, PPNP_SULDN
A6QCX3, PPNP_SULNBQ3A4X0, PPNP_SYNC1C5BHX0, PPNP_TERTT
Q3SHT2, PPNP_THIDAC4L823, PPNP_TOLATB3E2L0, PPNP_TRIL1
B7VTF8, PPNP_VIBA3A7N609, PPNP_VIBC1Q9KKY0, PPNP_VIBCH
Q87K41, PPNP_VIBPAQ8D4S0, PPNP_VIBVUQ7MGC2, PPNP_VIBVY
Q7MSS9, PPNP_WOLSUA1JNV1, PPNP_YERE8A7FLH4, PPNP_YERP3
Q1C4F4, PPNP_YERPAB2K6R0, PPNP_YERPBQ8ZC17, PPNP_YERPE
A9R2W2, PPNP_YERPGQ1CLB9, PPNP_YERPNA4TPJ3, PPNP_YERPP
Q66DY1, PPNP_YERPSB1JIG6, PPNP_YERPYQ23588, UTPP_CAEEL

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-