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ENZYME

ENZYME entry: EC 2.4.2.21

PURL: https://purl.expasy.org/enzyme/EC/2.4.2.21
Accepted Name
nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase
Alternative Name(s)
N(1)-alpha-phosphoribosyltransferase
nicotinate mononucleotide-dimethylbenzimidazole phosphoribosyltransferase
Reaction catalysed
5,6-dimethylbenzimidazole + nicotinate beta-D-ribonucleotide = alpha-ribazole 5'-phosphate + nicotinate + H(+)
Comment(s)
  • Also acts on benzimidazole, and the clostridial enzyme acts on adenine to form 7-alpha-D-ribosyladenine 5'-phosphate.
  • The product of the reaction, alpha-ribazole 5'-phosphate, forms part of the corrin biosynthesis pathway and is a substrate for EC 2.7.8.2.
  • It can also be dephosphorylated to form alpha-ribazole by the action of EC 3.1.3.73.
Cross-references
BRENDA2.4.2.21
EC2PDB2.4.2.21
ExplorEnz2.4.2.21
KEGG Ligand Database for Enzyme Nomenclature2.4.2.21
IUBMB Enzyme Nomenclature2.4.2.21
MEDLINEFind literature relating to 2.4.2.21
MetaCyc2.4.2.21
Rhea expert-curated reactions2.4.2.21
UniProtKB/Swiss-Prot
A3DF00, COBT_ACET2Q8UE71, COBT_AGRFCA6TKH4, COBT_ALKMQ
B9JW09, COBT_ALLAMQ5P2R4, COBT_AROAEA1KBH0, COBT_AZOSB
C1DPN9, COBT_AZOVDQ5LCE6, COBT_BACFNQ64TE4, COBT_BACFR
Q89Q54, COBT_BRADUA5EGF4, COBT_BRASBA4YXK4, COBT_BRASO
B2S5A1, COBT_BRUA1Q2YNK7, COBT_BRUA2A6X1H0, COBT_BRUA4
Q57DN9, COBT_BRUABA9MAP0, COBT_BRUC2C0RIK0, COBT_BRUMB
Q8YGQ9, COBT_BRUMEB0CLJ2, COBT_BRUSIQ8G155, COBT_BRUSU
A3PIN5, COBT_CERS1Q3J3P6, COBT_CERS4A4WRE3, COBT_CERS5
B9KQ95, COBT_CERSKA9WIQ7, COBT_CHLAAB8G806, COBT_CHLAD
Q3ARQ5, COBT_CHLCHB3QNS6, COBT_CHLP8A1BF69, COBT_CHLPD
A4SEC8, COBT_CHLPMB9LKQ0, COBT_CHLSYQ8KDU8, COBT_CHLTE
Q7P0S3, COBT_CHRVOB5EEL9, COBT_CITBBQ97JB4, COBT_CLOAB
Q180T6, COBT_CLOD6Q0TRK5, COBT_CLOP1Q8XLK7, COBT_CLOPE
Q891S7, COBT_CLOTEQ8FNQ2, COBT_COREFA4QFR5, COBT_CORGB
Q8NNJ8, COBT_CORGLQ0K7H7, COBT_CUPNHB3R647, COBT_CUPTR
Q47JS4, COBT_DECARA5FRG9, COBT_DEHMBQ3ZX54, COBT_DEHMC
Q9RYR8, COBT_DEIRAB1I4H2, COBT_DESAPQ6ALU4, COBT_DESPS
A4J829, COBT_DESRMA7ZNF5, COBT_ECO24B7UT20, COBT_ECO27
B7MDB7, COBT_ECO45B7L916, COBT_ECO55Q8X8V0, COBT_ECO57
B5YSS0, COBT_ECO5EB7NR83, COBT_ECO7IB7MWP8, COBT_ECO81
B7M3C7, COBT_ECO8AC4ZQQ4, COBT_ECOBWB1X6S9, COBT_ECODH
A8A1K5, COBT_ECOHSA1ACI8, COBT_ECOK1Q0TGE1, COBT_ECOL5
Q8FGA5, COBT_ECOL6B1IZQ9, COBT_ECOLCP36562, COBT_ECOLI
B7NC25, COBT_ECOLUB6I828, COBT_ECOSEB1LPV7, COBT_ECOSM
Q1RAB7, COBT_ECOUTA4XT55, COBT_ECTM1Q8RF14, COBT_FUSNN
B9LZU2, COBT_GEODFQ39YG4, COBT_GEOMGQ748J3, COBT_GEOSL
C6E7Q4, COBT_GEOSMA5G962, COBT_GEOURQ9KG31, COBT_HALH5
A9B732, COBT_HERA2A6SWY0, COBT_JANMAQ28M40, COBT_JANSC
Q04PD9, COBT_LEPBJQ055Y6, COBT_LEPBLQ72M35, COBT_LEPIC
Q8EYK9, COBT_LEPINQ9X7F4, COBT_METC4B8ERB9, COBT_METSB
A0QEZ9, COBT_MYCA1P63842, COBT_MYCBOA1KKP9, COBT_MYCBP
C1AQC2, COBT_MYCBTB8ZQK8, COBT_MYCLBO32953, COBT_MYCLE
B2HGX6, COBT_MYCMMQ73YK7, COBT_MYCPAA5U4N5, COBT_MYCTA
P9WP84, COBT_MYCTOP9WP85, COBT_MYCTUA0PTP2, COBT_MYCUA
Q725Z4, COBT_NITV2A1V9L9, COBT_NITV4Q2GBJ7, COBT_NOVAD
Q30US7, COBT_OLEA2A6LIW6, COBT_PARD8B4SH92, COBT_PELPB
Q7N2U4, COBT_PHOLLQ6LSY3, COBT_PHOPRA6L518, COBT_PHOV8
B2RIR0, COBT_PORG3Q7MWC6, COBT_PORGIB4S893, COBT_PROA2
Q48FJ9, COBT_PSE14B7UWH1, COBT_PSEA8Q02JC0, COBT_PSEAB
Q9I465, COBT_PSEAEQ1IDJ7, COBT_PSEE4Q4K8C1, COBT_PSEF5
C3K0Y8, COBT_PSEFSA5W7Q4, COBT_PSEP1Q3KFR5, COBT_PSEPF
B0KT67, COBT_PSEPGQ88M95, COBT_PSEPKB1J1N8, COBT_PSEPW
Q885W6, COBT_PSESMQ3IK32, COBT_PSET1Q4ZQ66, COBT_PSEU2
Q8XWS3, COBT_RALN1B3PQS3, COBT_RHIE6Q2K7G6, COBT_RHIEC
Q1MFK4, COBT_RHIJ3Q98KN9, COBT_RHILOB5ZSC4, COBT_RHILW
Q92P98, COBT_RHIMEB9JG15, COBT_RHIR8P0CY58, COBT_RHOCA
D5AV20, COBT_RHOCBA7NH25, COBT_ROSCSQ169A0, COBT_ROSDO
A5UQS8, COBT_ROSS1Q5LTJ1, COBT_RUEPOQ1GJ55, COBT_RUEST
B8I7A3, COBT_RUMCHB5EWY2, COBT_SALA4A9MLS8, COBT_SALAR
B5FLY4, COBT_SALDCB5QYX3, COBT_SALEPB5RBK6, COBT_SALG2
B4T8W8, COBT_SALHSB4SWC5, COBT_SALNSQ5PDU9, COBT_SALPA
A9MTA4, COBT_SALPBC0Q1R0, COBT_SALPCB5BG60, COBT_SALPK
B4TZP5, COBT_SALSVQ8Z5N9, COBT_SALTIA4XAM8, COBT_SALTO
Q05603, COBT_SALTYA1S3L3, COBT_SHEAMB8E4M8, COBT_SHEB2
A3D7X8, COBT_SHEB5A6WJZ1, COBT_SHEB8A9L3D8, COBT_SHEB9
Q086T6, COBT_SHEFNB0TT63, COBT_SHEHHA3QAT8, COBT_SHELP
Q8EI18, COBT_SHEONA4Y9P3, COBT_SHEPCB8CJ37, COBT_SHEPW
A0L0D3, COBT_SHESAA8FZR5, COBT_SHESHQ0HLZ5, COBT_SHESM
Q0HRU1, COBT_SHESRA1RGP1, COBT_SHESWB2TWR0, COBT_SHIB3
Q32ED0, COBT_SHIDSQ0T3C4, COBT_SHIF8Q83R14, COBT_SHIFL
Q3Z0K4, COBT_SHISSC3MDH9, COBT_SINFNA6U9W4, COBT_SINMW
C4XMZ1, COBT_SOLM1Q82AM7, COBT_STRAWQ9S2R1, COBT_STRCO
Q3A798, COBT_SYNC1A0LF21, COBT_SYNFMQ7SIC7, COBT_THET8
C5CKN8, COBT_VARPSB7VPD7, COBT_VIBA3A7MVW6, COBT_VIBC1
Q9KSL9, COBT_VIBCHQ87Q46, COBT_VIBPAQ8D921, COBT_VIBVU
Q7MLF3, COBT_VIBVYQ8PHR3, COBT_XANACQ4UXQ4, COBT_XANC8
B0RPU9, COBT_XANCBQ8P6B1, COBT_XANCPQ3BQB7, COBT_XANE5
Q2P631, COBT_XANOMB2SJ67, COBT_XANOPA1JTP8, COBT_YERE8
P29935, COBU_SINSX

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-