| Accepted Name |
|---|
| NAD(+) ADP-ribosyltransferase.
|
| Alternative Name(s) |
|---|
| ADP-ribosyltransferase (polymerizing). |
| Poly(adenosine diphosphate ribose) polymerase. |
| Poly(ADP-ribose) synthetase. |
| Poly(ADP-ribose)polymerase. |
| Reaction catalysed |
|---|
| NAD(+) + (ADP-D-ribosyl)(n)-acceptor <=> nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor |
| Comment(s) |
|---|
| The ADP-D-ribosyl group of NAD(+) is transferred to an acceptor
carboxy group on a histone or the enzyme itself, and further ADP-
ribosyl groups are transferred to the 2'-position of the terminal
adenosine moiety, building up a polymer with an average chain length
of 20-30 units.
|
| Cross-references |
|---|
| PROSITE | PDOC00360 ; PDOC51059 |
| BRENDA | 2.4.2.30 |
| EC2PDB | 2.4.2.30 |
| ExplorEnz | 2.4.2.30 |
| PRIAM enzyme-specific profiles | 2.4.2.30 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.4.2.30 |
| IUBMB Enzyme Nomenclature | 2.4.2.30 |
| IntEnz | 2.4.2.30 |
| MEDLINE | Find literature relating to 2.4.2.30 |
| MetaCyc | 2.4.2.30 |
| Rhea expert-curated reactions | 2.4.2.30 |
| UniProtKB/Swiss-Prot |
| Q9ZP54, PARP1_ARATH; | P18493, PARP1_BOVIN; | Q9N4H4, PARP1_CAEEL; |
| P26446, PARP1_CHICK; | Q9R152, PARP1_CRIGR; | P09874, PARP1_HUMAN; |
| Q9ZSV1, PARP1_MAIZE; | P11103, PARP1_MOUSE; | Q08824, PARP1_ONCMA; |
| Q7EYV7, PARP1_ORYSJ; | P27008, PARP1_RAT; | P31669, PARP1_XENLA; |
| Q11207, PARP2_ARATH; | Q09525, PARP2_CAEEL; | Q9UGN5, PARP2_HUMAN; |
| O50017, PARP2_MAIZE; | O88554, PARP2_MOUSE; | P35875, PARP_DROME; |
| O55721, PARP_IIV6; | B3EWG9, PARP_SACSO; | Q11208, PARP_SARPE; |
| Q5Z8Q9, PRP2A_ORYSJ; | Q0JMY1, PRP2B_ORYSJ; | Q9TXQ1, TNKS1_CAEEL; |
| O95271, TNKS1_HUMAN; | Q6PFX9, TNKS1_MOUSE; | Q9H2K2, TNKS2_HUMAN; |
| Q3UES3, TNKS2_MOUSE; | Q9VBP3, TNKS_DROME; | Q54YW4, Y8045_DICDI; |
|