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ENZYME

ENZYME entry: EC 2.4.2.43

Accepted Name
lipid IVA 4-amino-4-deoxy-L-arabinosyltransferase
Alternative Name(s)
4-amino-4-deoxy-L-arabinose lipid A transferase
lipid A 4-amino-4-deoxy-L-arabinosyltransferase
polymyxin resistance protein PmrK
undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase
undecaprenyl phosphate-alpha-L-Ara4N transferase
Reaction catalysed
4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + lipid IVA = lipid IIA + di-trans,octa-cis-undecaprenyl phosphate
Comment(s)
  • Integral membrane protein present in the inner membrane of certain Gram negative endobacteria.
  • In strains that do not produce 3-deoxy-D-manno-octulosonic acid (Kdo), the enzyme adds a single arabinose unit to the 1-phosphate moiety of the tetra-acylated lipid A precursor, lipid IVA.
  • In the presence of a Kdo disaccharide, the enzyme primarily adds an arabinose unit to the 4-phosphate of lipid A molecules.
  • The Salmonella typhimurium enzyme can add arabinose units to both positions.
  • Formerly EC 2.4.2.n1.
Cross-references
BRENDA2.4.2.43
EC2PDB2.4.2.43
ExplorEnz2.4.2.43
PRIAM enzyme-specific profiles2.4.2.43
KEGG Ligand Database for Enzyme Nomenclature2.4.2.43
IUBMB Enzyme Nomenclature2.4.2.43
IntEnz2.4.2.43
MEDLINEFind literature relating to 2.4.2.43
MetaCyc2.4.2.43
Rhea expert-curated reactions2.4.2.43
UniProtKB/Swiss-Prot
B4EUL1, ARNT1_PROMHQ4KC80, ARNT1_PSEF5Q3KCC9, ARNT1_PSEPF
Q2NWA9, ARNT1_SODGMB4ETL9, ARNT2_PROMHQ4K884, ARNT2_PSEF5
Q3KCB9, ARNT2_PSEPFQ2NRV9, ARNT2_SODGMA0KGY4, ARNT_AERHH
A4SQX1, ARNT_AERS4A7ZP75, ARNT_ECO24B7UFR9, ARNT_ECO27
B7MG24, ARNT_ECO45B7LAS2, ARNT_ECO55Q8XDZ1, ARNT_ECO57
B5YXQ0, ARNT_ECO5EB7NNT6, ARNT_ECO7IB7MXT9, ARNT_ECO81
B7M5T9, ARNT_ECO8AB1X8X0, ARNT_ECODHA8A2C4, ARNT_ECOHS
A1ADA9, ARNT_ECOK1Q0TFI5, ARNT_ECOL5Q8FFL9, ARNT_ECOL6
B1IXT0, ARNT_ECOLCP76473, ARNT_ECOLIB7N5M2, ARNT_ECOLU
B6I7K0, ARNT_ECOSEB1LLL1, ARNT_ECOSMQ1R9F8, ARNT_ECOUT
C5BDQ8, ARNT_EDWI9A4WAM1, ARNT_ENT38B2VBI7, ARNT_ERWT9
B7LM74, ARNT_ESCF3B5XTL1, ARNT_KLEP3A6TF96, ARNT_KLEP7
Q6D2F3, ARNT_PECASC6DAW3, ARNT_PECCPQ7N3Q9, ARNT_PHOLL
Q48HY9, ARNT_PSE14A6V1N8, ARNT_PSEA7B7VBN0, ARNT_PSEA8
Q02R27, ARNT_PSEABQ9HY61, ARNT_PSEAEQ4ZSZ0, ARNT_PSEU2
B5EZI0, ARNT_SALA4A9MJC5, ARNT_SALARQ57M54, ARNT_SALCH
B5FNU1, ARNT_SALDCB5R274, ARNT_SALEPB5RCC6, ARNT_SALG2
B4TBG8, ARNT_SALHSB4SYX3, ARNT_SALNSQ5PNA8, ARNT_SALPA
A9N5B0, ARNT_SALPBC0Q067, ARNT_SALPCB5BCP4, ARNT_SALPK
B4TPI4, ARNT_SALSVQ8Z538, ARNT_SALTIO52327, ARNT_SALTY
A8GDR9, ARNT_SERP5A8FRR0, ARNT_SHESHB2TW40, ARNT_SHIB3
Q31YK0, ARNT_SHIBSQ32DT1, ARNT_SHIDSQ0T2M6, ARNT_SHIF8
Q83KB6, ARNT_SHIFLQ3YZU9, ARNT_SHISSQ8D339, ARNT_WIGBR
A1JPM4, ARNT_YERE8A7FHH6, ARNT_YERP3Q1C744, ARNT_YERPA
B2K5L1, ARNT_YERPBQ8ZDX9, ARNT_YERPEA9R091, ARNT_YERPG
Q1CIH9, ARNT_YERPNA4TIM6, ARNT_YERPPQ66A06, ARNT_YERPS
B1JJ32, ARNT_YERPY

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-