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ENZYME entry: EC 2.4.2.43

Accepted Name
Lipid IV(A) 4-amino-4-deoxy-L-arabinosyltransferase.
Alternative Name(s)
4-amino-4-deoxy-L-arabinose lipid A transferase.
Lipid A 4-amino-4-deoxy-L-arabinosyltransferase.
Polymyxin resistance protein PmrK.
Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase.
Undecaprenyl phosphate-alpha-L-Ara4N transferase.
Reaction catalysed
4-amino-4-deoxy-alpha-L-arabinopyranosyl di-trans,octa-cis-undecaprenyl phosphate + lipid IV(A) <=> lipid II(A) + di-trans,octa-cis-undecaprenyl phosphate
Comment(s)
  • Integral membrane protein present in the inner membrane of certain Gram negative endobacteria.
  • In strains that do not produce 3-deoxy-D-manno-octulosonic acid (Kdo), the enzyme adds a single arabinose unit to the 1-phosphate moiety of the tetra-acylated lipid A precursor, lipid IV(A).
  • In the presence of a Kdo disaccharide, the enzyme primarily adds an arabinose unit to the 4-phosphate of lipid A molecules.
  • The Salmonella typhimurium enzyme can add arabinose units to both positions.
  • Formerly EC 2.4.2.n1.
Cross-references
BRENDA2.4.2.43
EC2PDB2.4.2.43
ExplorEnz2.4.2.43
PRIAM enzyme-specific profiles2.4.2.43
KEGG Ligand Database for Enzyme Nomenclature2.4.2.43
IUBMB Enzyme Nomenclature2.4.2.43
IntEnz2.4.2.43
MEDLINEFind literature relating to 2.4.2.43
MetaCyc2.4.2.43
Rhea expert-curated reactions2.4.2.43
UniProtKB/Swiss-Prot
B4EUL1, ARNT1_PROMH;  Q4KC80, ARNT1_PSEF5;  Q3KCC9, ARNT1_PSEPF;  
Q2NWA9, ARNT1_SODGM;  B4ETL9, ARNT2_PROMH;  Q4K884, ARNT2_PSEF5;  
Q3KCB9, ARNT2_PSEPF;  Q2NRV9, ARNT2_SODGM;  A0KGY4, ARNT_AERHH;  
A4SQX1, ARNT_AERS4;  A7ZP75, ARNT_ECO24;  B7UFR9, ARNT_ECO27;  
B7MG24, ARNT_ECO45;  B7LAS2, ARNT_ECO55;  Q8XDZ1, ARNT_ECO57;  
B5YXQ0, ARNT_ECO5E;  B7NNT6, ARNT_ECO7I;  B7MXT9, ARNT_ECO81;  
B7M5T9, ARNT_ECO8A;  B1X8X0, ARNT_ECODH;  A8A2C4, ARNT_ECOHS;  
A1ADA9, ARNT_ECOK1;  Q0TFI5, ARNT_ECOL5;  Q8FFL9, ARNT_ECOL6;  
B1IXT0, ARNT_ECOLC;  P76473, ARNT_ECOLI;  B7N5M2, ARNT_ECOLU;  
B6I7K0, ARNT_ECOSE;  B1LLL1, ARNT_ECOSM;  Q1R9F8, ARNT_ECOUT;  
C5BDQ8, ARNT_EDWI9;  A4WAM1, ARNT_ENT38;  B2VBI7, ARNT_ERWT9;  
B7LM74, ARNT_ESCF3;  B5XTL1, ARNT_KLEP3;  A6TF96, ARNT_KLEP7;  
Q6D2F3, ARNT_PECAS;  C6DAW3, ARNT_PECCP;  Q7N3Q9, ARNT_PHOLL;  
Q48HY9, ARNT_PSE14;  A6V1N8, ARNT_PSEA7;  B7VBN0, ARNT_PSEA8;  
Q02R27, ARNT_PSEAB;  Q9HY61, ARNT_PSEAE;  Q4ZSZ0, ARNT_PSEU2;  
B5EZI0, ARNT_SALA4;  A9MJC5, ARNT_SALAR;  Q57M54, ARNT_SALCH;  
B5FNU1, ARNT_SALDC;  B5R274, ARNT_SALEP;  B5RCC6, ARNT_SALG2;  
B4TBG8, ARNT_SALHS;  B4SYX3, ARNT_SALNS;  Q5PNA8, ARNT_SALPA;  
A9N5B0, ARNT_SALPB;  C0Q067, ARNT_SALPC;  B5BCP4, ARNT_SALPK;  
B4TPI4, ARNT_SALSV;  Q8Z538, ARNT_SALTI;  O52327, ARNT_SALTY;  
A8GDR9, ARNT_SERP5;  A8FRR0, ARNT_SHESH;  B2TW40, ARNT_SHIB3;  
Q31YK0, ARNT_SHIBS;  Q32DT1, ARNT_SHIDS;  Q0T2M6, ARNT_SHIF8;  
Q83KB6, ARNT_SHIFL;  Q3YZU9, ARNT_SHISS;  Q8D339, ARNT_WIGBR;  
A1JPM4, ARNT_YERE8;  A7FHH6, ARNT_YERP3;  Q1C744, ARNT_YERPA;  
B2K5L1, ARNT_YERPB;  Q8ZDX9, ARNT_YERPE;  A9R091, ARNT_YERPG;  
Q1CIH9, ARNT_YERPN;  A4TIM6, ARNT_YERPP;  Q66A06, ARNT_YERPS;  
B1JJ32, ARNT_YERPY;  

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