ENZYME entry: EC 2.4.2.61

PURL: https://purl.expasy.org/enzyme/EC/2.4.2.61

Accepted Name

alpha-dystroglycan beta1,4-xylosyltransferase

Reaction catalysed

3-O-[Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + UDP-alpha-D-xylose = 3-O-[beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + UDP + H(+)

Comment(s)

This eukaryotic enzyme catalyzes a step in the biosynthesis of the glycan moiety of the membrane protein alpha-dystroglycan.
It is specific for the second ribitol 5-phosphate in the nascent glycan chain as acceptor.

Cross-references

BRENDA

2.4.2.61

EC2PDB

2.4.2.61

ExplorEnz

2.4.2.61

KEGG Ligand Database for Enzyme Nomenclature

2.4.2.61

IUBMB Enzyme Nomenclature

2.4.2.61

MEDLINE

Find literature relating to 2.4.2.61

MetaCyc

2.4.2.61

Rhea expert-curated reactions

2.4.2.61

UniProtKB/Swiss-Prot

Q08CD5, RXLT1_DANRE

Q9Y2B1, RXLT1_HUMAN

Q8VDX6, RXLT1_MOUSE

View entry in original ENZYME format
View entry in raw text format (no links)

All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.

All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-