ENZYME

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ENZYME entry: EC 2.4.2.61

Accepted Name

alpha-dystroglycan beta1,4-xylosyltransferase.

Reaction catalysed

3-O-[Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + UDP-alpha-D-xylose <=> 3-O-[beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + H(+) + UDP

Comment(s)

This eukaryotic enzyme catalyzes a step in the biosynthesis of the glycan moiety of the membrane protein alpha-dystroglycan.
It is specific for the second ribitol 5-phosphate in the nascent glycan chain as acceptor.

Cross-references

BRENDA

2.4.2.61

EC2PDB

2.4.2.61

ExplorEnz

2.4.2.61

PRIAM enzyme-specific profiles

2.4.2.61

KEGG Ligand Database for Enzyme Nomenclature

2.4.2.61

IUBMB Enzyme Nomenclature

2.4.2.61

IntEnz

2.4.2.61

MEDLINE

Find literature relating to 2.4.2.61

MetaCyc

2.4.2.61

Rhea expert-curated reactions

2.4.2.61

UniProtKB/Swiss-Prot

Q08CD5, RXLT1_DANRE;

Q9Y2B1, RXLT1_HUMAN;

Q8VDX6, RXLT1_MOUSE;

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.2.-
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