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ENZYME

ENZYME entry: EC 2.4.2.61

PURL: https://purl.expasy.org/enzyme/EC/2.4.2.61
Accepted Name
alpha-dystroglycan beta1,4-xylosyltransferase
Reaction catalysed
3-O-[Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + UDP-alpha-D-xylose = 3-O-[beta-D-Xyl-(1->4)-Rib-ol-P-Rib-ol-P-3-beta-D-GalNAc-(1->3)-beta-D-GlcNAc-(1->4)-(O-6-P-alpha-D-Man)]-Thr-[protein] + UDP + H(+)
Comment(s)
  • This eukaryotic enzyme catalyzes a step in the biosynthesis of the glycan moiety of the membrane protein alpha-dystroglycan.
  • It is specific for the second ribitol 5-phosphate in the nascent glycan chain as acceptor.
Cross-references
Rhea expert-curated reactions2.4.2.61
ExplorEnz2.4.2.61
IUBMB Enzyme Nomenclature2.4.2.61
UniProtKB/Swiss-Prot
Q08CD5, RXLT1_DANREQ9Y2B1, RXLT1_HUMANQ8VDX6, RXLT1_MOUSE
BRENDA2.4.2.61
MetaCyc2.4.2.61
KEGG Ligand Database for Enzyme Nomenclature2.4.2.61
EC2PDB2.4.2.61
MEDLINEFind literature relating to 2.4.2.61

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