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ENZYME entry: EC 2.4.2.8

Accepted Name
Hypoxanthine phosphoribosyltransferase.
Alternative Name(s)
Guanine phosphoribosyltransferase.
HGPRTase.
Hypoxanthine-guanine phosphoribosyltransferase.
IMP diphosphorylase.
IMP pyrophosphorylase.
Transphosphoribosidase.
Reaction catalysed
IMP + diphosphate <=> hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate
Comment(s)
Guanine and 6-mercaptopurine can replace hypoxanthine.
Cross-references
PROSITEPDOC00096
BRENDA2.4.2.8
EC2PDB2.4.2.8
ExplorEnz2.4.2.8
PRIAM enzyme-specific profiles2.4.2.8
KEGG Ligand Database for Enzyme Nomenclature2.4.2.8
IUBMB Enzyme Nomenclature2.4.2.8
IntEnz2.4.2.8
MEDLINEFind literature relating to 2.4.2.8
MetaCyc2.4.2.8
UniProtKB/Swiss-Prot
O66821, HGPRT_AQUAE;  P37472, HGPRT_BACSU;  Q839B2, HGPRT_ENTFA;  
Q02522, HGPRT_LACLA;  P96794, HGPRT_MYCAV;  P0A5T1, HGPRT_MYCBO;  
P47696, HGPRT_MYCGE;  O69537, HGPRT_MYCLE;  P75119, HGPRT_MYCPN;  
P9WHQ8, HGPRT_MYCTO;  P9WHQ9, HGPRT_MYCTU;  P37171, HGPRT_RHOCB;  
Q5HIG5, HGPRT_STAAC;  P65827, HGPRT_STAAM;  P99085, HGPRT_STAAN;  
Q6GJG1, HGPRT_STAAR;  Q6GBX8, HGPRT_STAAS;  P65828, HGPRT_STAAW;  
Q5HRP4, HGPRT_STAEQ;  Q8CQV4, HGPRT_STAES;  Q8E7Y1, HGPRT_STRA3;  
Q8E2H3, HGPRT_STRA5;  Q8DWM8, HGPRT_STRMU;  P0DD40, HGPRT_STRP3;  
Q5XEL6, HGPRT_STRP6;  Q7CNQ9, HGPRT_STRP8;  Q97TC4, HGPRT_STRPN;  
P0DD41, HGPRT_STRPQ;  Q8DRP8, HGPRT_STRR6;  Q5M216, HGPRT_STRT1;  
Q5M6K8, HGPRT_STRT2;  P20035, HGXR_PLAFG;  P07833, HGXR_PLAFK;  
Q26997, HGXR_TOXGO;  P51900, HGXR_TRIFO;  B5IAJ6, HPRT_ACIB4;  
Q3SZ18, HPRT_BOVIN;  P57291, HPRT_BUCAI;  Q8K9U8, HPRT_BUCAP;  
Q6WIT9, HPRT_CANLF;  Q9W719, HPRT_CHICK;  Q27541, HPRT_CRIFA;  
P00494, HPRT_CRIGR;  Q54NJ8, HPRT_DICDI;  P0A9M3, HPRT_ECOL6;  
P0A9M2, HPRT_ECOLI;  D3S0H7, HPRT_FERPA;  P45078, HPRT_HAEIN;  
P00492, HPRT_HUMAN;  P43152, HPRT_LEIDO;  Q6LDD9, HPRT_MACFA;  
P47959, HPRT_MERUN;  A6UX50, HPRT_META3;  Q8TSS8, HPRT_METAC;  
Q0W496, HPRT_METAR;  Q46C14, HPRT_METBF;  Q12W31, HPRT_METBU;  
D7E9E7, HPRT_METEZ;  C7P7L7, HPRT_METFA;  E3GW42, HPRT_METFV;  
Q2FSD3, HPRT_METHJ;  F6BB32, HPRT_METIK;  D5VT38, HPRT_METIM;  
Q59049, HPRT_METJA;  Q8TXQ0, HPRT_METKA;  F0T7W2, HPRT_METLA;  
A2SPY9, HPRT_METLZ;  A4G043, HPRT_METM5;  A9A8E9, HPRT_METM6;  
A6VID5, HPRT_METM7;  Q8PVT4, HPRT_METMA;  Q6M0X3, HPRT_METMP;  
D5E7U7, HPRT_METMS;  F8AJL1, HPRT_METOI;  B8GDM8, HPRT_METPE;  
D1YVK0, HPRT_METPS;  F6D512, HPRT_METPW;  D3DYU7, HPRT_METRM;  
D3S8C7, HPRT_METSF;  F4BT36, HPRT_METSG;  O27375, HPRT_METTH;  
O33174, HPRT_METTM;  A0B870, HPRT_METTP;  D7DQT8, HPRT_METV3;  
C9RH78, HPRT_METVM;  A6URC7, HPRT_METVS;  F7XQS2, HPRT_METZD;  
P00493, HPRT_MOUSE;  Q64531, HPRT_MUSSP;  A5A6I1, HPRT_PANTR;  
Q45FY6, HPRT_PIG;  P27605, HPRT_RAT;  O33799, HPRT_SALTY;  
P09383, HPRT_SCHMA;  O13917, HPRT_SCHPO;  P0A9M4, HPRT_SHIFL;  
Q07010, HPRT_TRYBB;  P18134, HPRT_VIBHA;  Q04178, HPRT_YEAST;  
Q92F56, TILS_LISIN;  Q724J4, TILS_LISMF;  Q8YAC7, TILS_LISMO;  

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