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ENZYME entry: EC 2.4.2.n3

Accepted Name
Xylosyl alpha-1,3-xylosyltransferase.
Reaction catalysed
UDP-alpha-D-xylose + [protein with EGF-like domain]-3-O-(alpha-D-xylosyl-(1->3)-beta-D-glucosyl)-L-serine <=> UDP + [protein with EGF-like domain]-3-O-(alpha-D-xylosyl-(1->3)-alpha-D-xylosyl-(1->3)-beta-D-glucosyl)-L-serine
Comment(s)
  • The enzyme, found in animals and insects, is involved in the biosynthesis of the alpha-D-xylosyl-(1->3)-alpha-D-xylosyl-(1->3)- beta-D-glucosyl trisaccharide on epidermal growth factor-like (EGF- like) domains.
  • When present on Notch proteins, the trisaccharide functions as a modulator of the signaling activity of this protein.
  • Formerly EC 2.4.2.n3.
Cross-references
UniProtKB/Swiss-Prot
Q8NBI6, XXLT1_HUMAN;  Q3U4G3, XXLT1_MOUSE;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.2.-
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