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ENZYME entry: EC 2.4.3.10

Accepted Name
N-acetylglucosaminide alpha-(2,6)-sialyltransferase.
Alternative Name(s)
alpha-N-acetylneuraminyl-2,3-beta-galactosyl-1,3-N-acetylglucosaminide 6-alpha-sialyltransferase.
N-acetylglucosaminide (alpha 2->6)-sialyltransferase.
ST6GlcNAc.
Reaction catalysed
an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate <=> an alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-[alpha-Neu5Ac-(2->6)]-beta-D-GlcNAc-R + CMP + H(+)
Comment(s)
  • Attaches N-acetylneuraminic acid in alpha-2,6-linkage to N-acetyl- beta-D-glucosamine.
  • The enzyme from rat liver also acts on beta-D-galactosyl-(1->3)-N- acetyl-beta-D-glucosaminyl residues, but more slowly.
  • Formerly EC 2.4.99.22.
Cross-references
BRENDA2.4.3.10
EC2PDB2.4.3.10
ExplorEnz2.4.3.10
PRIAM enzyme-specific profiles2.4.3.10
KEGG Ligand Database for Enzyme Nomenclature2.4.3.10
IUBMB Enzyme Nomenclature2.4.3.10
IntEnz2.4.3.10
MEDLINEFind literature relating to 2.4.3.10
MetaCyc2.4.3.10
Rhea expert-curated reactions2.4.3.10

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.3.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-