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ENZYME

ENZYME entry: EC 2.4.3.2

PURL: https://purl.expasy.org/enzyme/EC/2.4.3.2
Accepted Name
beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminide alpha-2,3- sialyltransferase
Alternative Name(s)
monosialoganglioside sialyltransferase
Reaction catalysed
a beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl derivative + CMP + H(+)
Comment(s)
  • The enzyme recognizes the sequence beta-D-galactosyl-(1->3)-N-acetyl- D-galactosaminyl (known as type 1 histo-blood group precursor disaccharide) in non-reducing termini of glycan moieties in glycoproteins and glycolipids.
  • When acting on gangloside GM1a, it forms gangloside GD1a.
  • Formerly EC 2.4.99.2.
Cross-references
BRENDA2.4.3.2
EC2PDB2.4.3.2
ExplorEnz2.4.3.2
KEGG Ligand Database for Enzyme Nomenclature2.4.3.2
IUBMB Enzyme Nomenclature2.4.3.2
MEDLINEFind literature relating to 2.4.3.2
MetaCyc2.4.3.2
Rhea expert-curated reactions2.4.3.2
UniProtKB/Swiss-Prot
Q11201, SIA4A_HUMANP54751, SIA4A_MOUSEQ6KB59, SIA4A_PANTR
Q02745, SIA4A_PIGQ16842, SIA4B_HUMANQ11204, SIA4B_MOUSE
Q6KB58, SIA4B_PANTRQ11205, SIA4B_RATQ11206, SIA4C_HUMAN
Q91Y74, SIA4C_MOUSEP61130, SIA4C_PANTRP61131, SIA4C_RAT

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.3.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-