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ENZYME entry: EC 2.4.3.3

Accepted Name
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase.
Alternative Name(s)
GalNAc alpha-2,6-sialyltransferase I.
Reaction catalysed
a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate <=> a beta-D-galactosyl-(1->3)-[N-acetyl-alpha-neuraminyl-(2->6)]-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+)
Comment(s)
  • N-acetyl-alpha-D-galactosamine linked to threonine or serine is also an acceptor, when substituted at the 3-position.
  • Formerly EC 2.4.99.3.
Cross-references
BRENDA2.4.3.3
EC2PDB2.4.3.3
ExplorEnz2.4.3.3
PRIAM enzyme-specific profiles2.4.3.3
KEGG Ligand Database for Enzyme Nomenclature2.4.3.3
IUBMB Enzyme Nomenclature2.4.3.3
IntEnz2.4.3.3
MEDLINEFind literature relating to 2.4.3.3
MetaCyc2.4.3.3
Rhea expert-curated reactions2.4.3.3
UniProtKB/Swiss-Prot
Q92183, SIA7A_CHICK;  Q9NSC7, SIA7A_HUMAN;  Q9QZ39, SIA7A_MOUSE;  
Q92184, SIA7B_CHICK;  Q9UJ37, SIA7B_HUMAN;  P70277, SIA7B_MOUSE;  

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