Expasy logo

ENZYME

ENZYME entry: EC 2.4.3.6

PURL: https://purl.expasy.org/enzyme/EC/2.4.3.6
Accepted Name
N-acetyllactosaminide alpha-2,3-sialyltransferase
Alternative Name(s)
alpha2->3 sialyltransferase
cytidine monophosphoacetylneuraminate-beta- galactosyl(1->4)acetylglucosaminide alpha2->3-sialyltransferase
neolactotetraosylceramide alpha-2,3-sialyltransferase
Reaction catalysed
a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP + H(+)
Comment(s)
  • The enzyme recognizes the sequence beta-D-galactosyl-(1->4)-N-acetyl- D-glucosaminyl (known as type 2 histo-blood group precursor disaccharide) in non-reducing termini of glycan moieties in glycoproteins and glycolipids.
  • The enzyme from chicken brain was shown to act on neolactotetraosylceramide, producing ganglioside LM1.
  • Formerly EC 2.4.99.6.
Cross-references
Rhea expert-curated reactions2.4.3.6
ExplorEnz2.4.3.6
IUBMB Enzyme Nomenclature2.4.3.6
UniProtKB/Swiss-Prot
Q48211, LST_HAEINP72074, LST_NEIGOQ9JUV5, LST_NEIMA
P72097, LST_NEIMBQ15KI8, PMST1_PASMDQ6H8M7, SIA10_BOVIN
Q9Y274, SIA10_HUMANQ8VIB3, SIA10_MOUSEQ6KB54, SIA10_PANTR
Q5RE85, SIA10_PONABP61943, SIA10_RATQ11206, SIA4C_HUMAN
Q91Y74, SIA4C_MOUSEP61130, SIA4C_PANTRP61131, SIA4C_RAT
Q11203, SIAT6_HUMANP97325, SIAT6_MOUSEP61132, SIAT6_PANTR
Q02734, SIAT6_RAT
BRENDA2.4.3.6
MetaCyc2.4.3.6
KEGG Ligand Database for Enzyme Nomenclature2.4.3.6
MEDLINEFind literature relating to 2.4.3.6

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.3.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-