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ENZYME

ENZYME entry: EC 2.4.3.6

Accepted Name
N-acetyllactosaminide alpha-2,3-sialyltransferase
Alternative Name(s)
alpha2->3 sialyltransferase
cytidine monophosphoacetylneuraminate-beta- galactosyl(1->4)acetylglucosaminide alpha2->3-sialyltransferase
neolactotetraosylceramide alpha-2,3-sialyltransferase
Reaction catalysed
a beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP-N-acetyl-beta-neuraminate = an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminyl derivative + CMP + H(+)
Comment(s)
  • The enzyme recognizes the sequence beta-D-galactosyl-(1->4)-N-acetyl- D-glucosaminyl (known as type 2 histo-blood group precursor disaccharide) in non-reducing termini of glycan moieties in glycoproteins and glycolipids.
  • The enzyme from chicken brain was shown to act on neolactotetraosylceramide, producing ganglioside LM1.
  • Formerly EC 2.4.99.6.
Cross-references
BRENDA2.4.3.6
EC2PDB2.4.3.6
ExplorEnz2.4.3.6
PRIAM enzyme-specific profiles2.4.3.6
KEGG Ligand Database for Enzyme Nomenclature2.4.3.6
IUBMB Enzyme Nomenclature2.4.3.6
IntEnz2.4.3.6
MEDLINEFind literature relating to 2.4.3.6
MetaCyc2.4.3.6
Rhea expert-curated reactions2.4.3.6
UniProtKB/Swiss-Prot
Q48211, LST_HAEINP72074, LST_NEIGOQ9JUV5, LST_NEIMA
P72097, LST_NEIMBQ6H8M7, SIA10_BOVINQ9Y274, SIA10_HUMAN
Q8VIB3, SIA10_MOUSEQ6KB54, SIA10_PANTRQ5RE85, SIA10_PONAB
P61943, SIA10_RATQ11206, SIA4C_HUMANQ91Y74, SIA4C_MOUSE
P61130, SIA4C_PANTRP61131, SIA4C_RATQ11203, SIAT6_HUMAN
P97325, SIAT6_MOUSEP61132, SIAT6_PANTRQ02734, SIAT6_RAT

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.3.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-