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ENZYME entry: EC 2.4.3.8

Accepted Name
alpha-N-acetylneuraminate alpha-2,8-sialyltransferase.
Alternative Name(s)
alpha-2,8-sialyltransferase.
cytidine monophosphoacetylneuraminate-ganglioside GM3.
ganglioside GD3 synthase.
ganglioside GD3 synthetase sialyltransferase.
Reaction catalysed
an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl derivative + CMP-N-acetyl-beta-neuraminate <=> an N-acetyl-alpha-neuraminyl-(2->8)-N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl derivative + CMP + H(+)
Comment(s)
  • Gangliosides act as acceptors.
  • Formerly EC 2.4.99.8.
Cross-references
BRENDA2.4.3.8
EC2PDB2.4.3.8
ExplorEnz2.4.3.8
PRIAM enzyme-specific profiles2.4.3.8
KEGG Ligand Database for Enzyme Nomenclature2.4.3.8
IUBMB Enzyme Nomenclature2.4.3.8
IntEnz2.4.3.8
MEDLINEFind literature relating to 2.4.3.8
MetaCyc2.4.3.8
Rhea expert-curated reactions2.4.3.8
UniProtKB/Swiss-Prot
Q6ZXD2, SIA8A_BOVIN;  Q92185, SIA8A_HUMAN;  Q64687, SIA8A_MOUSE;  
P61642, SIA8A_PANTR;  Q6ZXA0, SIA8A_XENLA;  Q6DNG6, SIA8A_XENTR;  

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