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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 2.4.99.1

Accepted Name
Beta-galactoside alpha-(2,6)-sialyltransferase.
Alternative Name(s)
Beta-galactosamide alpha-2,6-sialyltransferase.
Beta-galactoside alpha-2,6-sialyltransferase.
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase.
Lactosylceramide-alpha-2,6-N-sialyltransferase.
Reaction catalysed
CMP-N-acetyl-beta-neuraminate + beta-D-galactosyl-R <=> CMP + N-acetyl-alpha-neuraminyl-(2->6)-beta-D-galactosyl-R
Comment(s)
  • The enzyme acts on the terminal non-reducing beta-D-galactosyl residue of the oligosaccharide moiety of glycoproteins and glycolipids.
  • Formerly EC 2.4.99.11.
Cross-references
BRENDA2.4.99.1
EC2PDB2.4.99.1
ExplorEnz2.4.99.1
PRIAM enzyme-specific profiles2.4.99.1
KEGG Ligand Database for Enzyme Nomenclature2.4.99.1
IUBMB Enzyme Nomenclature2.4.99.1
IntEnz2.4.99.1
MEDLINEFind literature relating to 2.4.99.1
MetaCyc2.4.99.1
UniProtKB/Swiss-Prot
Q92182, SIAT1_CHICK;  P15907, SIAT1_HUMAN;  Q64685, SIAT1_MOUSE;  
P13721, SIAT1_RAT;  A5D7T4, SIAT2_BOVIN;  Q701R0, SIAT2_CHICK;  
Q701R2, SIAT2_DANRE;  Q96JF0, SIAT2_HUMAN;  Q76K27, SIAT2_MOUSE;  
Q5K027, SIAT2_ORYLA;  Q701R4, SIAT2_PANTR;  Q701R3, SIAT2_RAT;  
Q5QQ37, SIAT2_TAKRU;  Q701R1, SIAT2_XENTR;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.99.-
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