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ENZYME entry: EC 2.4.99.12

Accepted Name
lipid IVA 3-deoxy-D-manno-octulosonic acid transferase.
Alternative Name(s)
3-deoxy-D-manno-oct-2-ulosonic acid transferase.
3-deoxy-manno-octulosonic acid transferase.
KDO transferase.
lipid IVA KDO transferase.
Reaction catalysed
CMP-3-deoxy-beta-D-manno-octulosonate + lipid IVA (E. coli) <=> alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)
Comment(s)
  • The enzyme from Escherichia coli is bifunctional and transfers two 3-deoxy-D-manno-oct-2-ulosonate residues to lipid IVA (cf. EC 2.4.99.13).
  • The monofunctional enzymes from Bordetella pertusis, Aquifex aeolicus and Haemophilus influenzae catalyze the transfer of a single 3-D- manno-oct-2-ulosonate residue from CMP-3-D-manno-oct-2-ulosonate to lipid IVA.
  • The enzymes from Chlamydia transfer three or more 3-deoxy-D-manno- oct-2-ulosonate residues and generate genus-specific epitopes.
Cross-references
BRENDA2.4.99.12
EC2PDB2.4.99.12
ExplorEnz2.4.99.12
PRIAM enzyme-specific profiles2.4.99.12
KEGG Ligand Database for Enzyme Nomenclature2.4.99.12
IUBMB Enzyme Nomenclature2.4.99.12
IntEnz2.4.99.12
MEDLINEFind literature relating to 2.4.99.12
MetaCyc2.4.99.12
Rhea expert-curated reactions2.4.99.12
UniProtKB/Swiss-Prot
O66663, KDTA_AQUAE;  Q8VZA5, KDTA_ARATH;  Q45374, KDTA_BORPT;  
Q9PKI5, KDTA_CHLMU;  F0T4D1, KDTA_CHLP6;  Q46222, KDTA_CHLPN;  
B0B9V8, KDTA_CHLT2;  Q3KMF4, KDTA_CHLTA;  P0CE14, KDTA_CHLTR;  
P0AC77, KDTA_ECO57;  P0AC76, KDTA_ECOL6;  P0AC75, KDTA_ECOLI;  
P44806, KDTA_HAEIN;  Q1RGU8, KDTA_RICBR;  Q92JE9, KDTA_RICCN;  
Q4UND5, KDTA_RICFE;  Q9ZE58, KDTA_RICPR;  Q68XV7, KDTA_RICTY;  

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