Expasy logo

ENZYME

ENZYME entry: EC 2.4.99.12

PURL: https://purl.expasy.org/enzyme/EC/2.4.99.12
Accepted Name
lipid IVA 3-deoxy-D-manno-octulosonic acid transferase
Alternative Name(s)
3-deoxy-D-manno-oct-2-ulosonic acid transferase
3-deoxy-manno-octulosonic acid transferase
KDO transferase
lipid IVA KDO transferase
Reaction catalysed
a lipid IVA + CMP-3-deoxy-beta-D-manno-octulosonate = an alpha-Kdo-(2->6)-lipid IVA + CMP + H(+)
Comment(s)
  • The enzyme from Escherichia coli is bifunctional and transfers two 3-deoxy-D-manno-oct-2-ulosonate residues to lipid IVA (cf. EC 2.4.99.13).
  • The monofunctional enzymes from Bordetella pertusis, Aquifex aeolicus and Haemophilus influenzae catalyze the transfer of a single 3-D- manno-oct-2-ulosonate residue from CMP-3-D-manno-oct-2-ulosonate to lipid IVA.
  • The enzymes from Chlamydia transfer three or more 3-deoxy-D-manno- oct-2-ulosonate residues and generate genus-specific epitopes.
Cross-references
BRENDA2.4.99.12
EC2PDB2.4.99.12
ExplorEnz2.4.99.12
KEGG Ligand Database for Enzyme Nomenclature2.4.99.12
IUBMB Enzyme Nomenclature2.4.99.12
MEDLINEFind literature relating to 2.4.99.12
MetaCyc2.4.99.12
Rhea expert-curated reactions2.4.99.12
UniProtKB/Swiss-Prot
O66663, KDTA_AQUAEQ8VZA5, KDTA_ARATHQ45374, KDTA_BORPT
Q9PKI5, KDTA_CHLMUF0T4D1, KDTA_CHLP6Q46222, KDTA_CHLPN
B0B9V8, KDTA_CHLT2Q3KMF4, KDTA_CHLTAP0CE14, KDTA_CHLTR
P0AC77, KDTA_ECO57P0AC76, KDTA_ECOL6P0AC75, KDTA_ECOLI
P44806, KDTA_HAEINQ1RGU8, KDTA_RICBRQ92JE9, KDTA_RICCN
Q4UND5, KDTA_RICFEQ9ZE58, KDTA_RICPRQ68XV7, KDTA_RICTY

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.99.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-