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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 2.4.99.12

Accepted Name
Lipid IV(A) 3-deoxy-D-manno-octulosonic acid transferase.
Alternative Name(s)
3-deoxy-D-manno-oct-2-ulosonic acid transferase.
3-deoxy-manno-octulosonic acid transferase.
KDO transferase.
Lipid IV(A) KDO transferase.
Reaction catalysed
Lipid IV(A) + CMP-beta-Kdo <=> alpha-Kdo-(2->6)-lipid IV(A) + CMP
Comment(s)
  • The bifunctional enzyme from Escherichia coli transfers two 3-deoxy- D-manno-octulosonate residues to lipid IV(A) (cf. EC 2.4.99.13).
  • The monofunctional enzymes from Aquifex aeolicus and Haemophilus influenzae catalyze the transfer of a single 3-deoxy-D-manno- octulosonate residue from CMP-3-deoxy-D-manno-octulosonate to lipid IV(A).
  • The enzymes from Chlamydia transfer three or more 3-deoxy-D-manno- octulosonate residues and generate genus-specific epitopes.
Cross-references
BRENDA2.4.99.12
EC2PDB2.4.99.12
ExplorEnz2.4.99.12
PRIAM enzyme-specific profiles2.4.99.12
KEGG Ligand Database for Enzyme Nomenclature2.4.99.12
IUBMB Enzyme Nomenclature2.4.99.12
IntEnz2.4.99.12
MEDLINEFind literature relating to 2.4.99.12
MetaCyc2.4.99.12
UniProtKB/Swiss-Prot
O66663, KDTA_AQUAE;  Q8VZA5, KDTA_ARATH;  Q45374, KDTA_BORPT;  
Q9PKI5, KDTA_CHLMU;  F0T4D1, KDTA_CHLP6;  Q46222, KDTA_CHLPN;  
B0B9V8, KDTA_CHLT2;  Q3KMF4, KDTA_CHLTA;  P0CE14, KDTA_CHLTR;  
P0AC77, KDTA_ECO57;  P0AC76, KDTA_ECOL6;  P0AC75, KDTA_ECOLI;  
P44806, KDTA_HAEIN;  Q1RGU8, KDTA_RICBR;  Q92JE9, KDTA_RICCN;  
Q4UND5, KDTA_RICFE;  Q9ZE58, KDTA_RICPR;  Q68XV7, KDTA_RICTY;  

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