A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 2.4.99.12
| Accepted Name |
|---|
| Lipid IV(A) 3-deoxy-D-manno-octulosonic acid transferase.
|
| Alternative Name(s) |
|---|
| 3-deoxy-D-manno-oct-2-ulosonic acid transferase. |
| 3-deoxy-manno-octulosonic acid transferase. |
| KDO transferase. |
| Lipid IV(A) KDO transferase. |
| Reaction catalysed |
|---|
| Lipid IV(A) + CMP-beta-Kdo <=> alpha-Kdo-(2->6)-lipid IV(A) + CMP |
| Comment(s) |
|---|
- The bifunctional enzyme from Escherichia coli transfers two 3-deoxy-
D-manno-octulosonate residues to lipid IV(A) (cf. EC 2.4.99.13).
- The monofunctional enzymes from Aquifex aeolicus and Haemophilus
influenzae catalyze the transfer of a single 3-deoxy-D-manno-
octulosonate residue from CMP-3-deoxy-D-manno-octulosonate to lipid
IV(A).
- The enzymes from Chlamydia transfer three or more 3-deoxy-D-manno-
octulosonate residues and generate genus-specific epitopes.
|
| Cross-references |
|---|
| BRENDA | 2.4.99.12 |
| EC2PDB | 2.4.99.12 |
| ExplorEnz | 2.4.99.12 |
| PRIAM enzyme-specific profiles | 2.4.99.12 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.4.99.12 |
| IUBMB Enzyme Nomenclature | 2.4.99.12 |
| IntEnz | 2.4.99.12 |
| MEDLINE | Find literature relating to 2.4.99.12 |
| MetaCyc | 2.4.99.12 |
| UniProtKB/Swiss-Prot |
| O66663, KDTA_AQUAE; | Q8VZA5, KDTA_ARATH; | Q45374, KDTA_BORPT; |
| Q9PKI5, KDTA_CHLMU; | F0T4D1, KDTA_CHLP6; | Q46222, KDTA_CHLPN; |
| B0B9V8, KDTA_CHLT2; | Q3KMF4, KDTA_CHLTA; | P0CE14, KDTA_CHLTR; |
| P0AC77, KDTA_ECO57; | P0AC76, KDTA_ECOL6; | P0AC75, KDTA_ECOLI; |
| P44806, KDTA_HAEIN; | Q1RGU8, KDTA_RICBR; | Q92JE9, KDTA_RICCN; |
| Q4UND5, KDTA_RICFE; | Q9ZE58, KDTA_RICPR; | Q68XV7, KDTA_RICTY; |
|
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