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ENZYME entry: EC 2.4.99.4

Accepted Name
beta-galactoside alpha-2,3-sialyltransferase.
Alternative Name(s)
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase.
Reaction catalysed
a beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP-N-acetyl-beta-neuraminate <=> an N-acetyl-alpha-neuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl derivative + CMP + H(+)
Comment(s)
  • The acceptor is Gal-beta-1,3-GalNAc-R, where R is H, a threonine or serine residue in a glycoprotein, or a glycolipid.
  • Lactose can also act as acceptor.
  • May be identical with EC 2.4.99.2.
Cross-references
BRENDA2.4.99.4
EC2PDB2.4.99.4
ExplorEnz2.4.99.4
PRIAM enzyme-specific profiles2.4.99.4
KEGG Ligand Database for Enzyme Nomenclature2.4.99.4
IUBMB Enzyme Nomenclature2.4.99.4
IntEnz2.4.99.4
MEDLINEFind literature relating to 2.4.99.4
MetaCyc2.4.99.4
Rhea expert-curated reactions2.4.99.4
UniProtKB/Swiss-Prot
Q11200, SIA4A_CHICK;  Q11201, SIA4A_HUMAN;  P54751, SIA4A_MOUSE;  
Q6KB59, SIA4A_PANTR;  Q02745, SIA4A_PIG;  Q16842, SIA4B_HUMAN;  
Q11204, SIA4B_MOUSE;  Q6KB58, SIA4B_PANTR;  Q11205, SIA4B_RAT;  
Q11206, SIA4C_HUMAN;  Q91Y74, SIA4C_MOUSE;  P61130, SIA4C_PANTR;  
P61131, SIA4C_RAT;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.4.99.-
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