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ENZYME entry: EC 2.4.99.9

Accepted Name
Lactosylceramide alpha-2,3-sialyltransferase.
Alternative Name(s)
Ganglioside GM3 synthase.
Reaction catalysed
CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide <=> CMP + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1)-ceramide
Comment(s)
Lactose cannot act as acceptor.
Cross-references
BRENDA2.4.99.9
EC2PDB2.4.99.9
ExplorEnz2.4.99.9
PRIAM enzyme-specific profiles2.4.99.9
KEGG Ligand Database for Enzyme Nomenclature2.4.99.9
IUBMB Enzyme Nomenclature2.4.99.9
IntEnz2.4.99.9
MEDLINEFind literature relating to 2.4.99.9
MetaCyc2.4.99.9
Rhea expert-curated reactions2.4.99.9
UniProtKB/Swiss-Prot
Q70D51, SIAT9_BOVIN;  Q9UNP4, SIAT9_HUMAN;  O88829, SIAT9_MOUSE;  
Q6KB55, SIAT9_PANTR;  Q68G12, SIAT9_RAT;  

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