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ENZYME entry: EC 2.5.1.108

Accepted Name
2-(3-amino-3-carboxypropyl)histidine synthase.
Reaction catalysed
L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine <=> 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + H(+) + S-methyl-5'-thioadenosine
Comment(s)
  • Modifies a histidine residue of the translation elongation factor 2 (EF2) via a 3-amino-3-carboxypropyl radical.
  • The enzyme is present in archae and eukaryotes but not in eubacteria.
  • Part of diphthamide biosynthesis.
  • Formerly EC 2.5.1.n7.
Cross-references
BRENDA2.5.1.108
EC2PDB2.5.1.108
ExplorEnz2.5.1.108
PRIAM enzyme-specific profiles2.5.1.108
KEGG Ligand Database for Enzyme Nomenclature2.5.1.108
IUBMB Enzyme Nomenclature2.5.1.108
IntEnz2.5.1.108
MEDLINEFind literature relating to 2.5.1.108
MetaCyc2.5.1.108
Rhea expert-curated reactions2.5.1.108
UniProtKB/Swiss-Prot
Q75AZ9, DPH1_ASHGO;  Q4X0S7, DPH1_ASPFU;  Q3SYT1, DPH1_BOVIN;  
P49958, DPH1_CAEEL;  Q59MG1, DPH1_CANAL;  Q6FTG1, DPH1_CANGA;  
Q5ZHX9, DPH1_CHICK;  A0A8C2MDK8, DPH1_CRIGR;  P0CN19, DPH1_CRYNB;  
P0CN18, DPH1_CRYNJ;  Q567W6, DPH1_DANRE;  Q6BPU5, DPH1_DEBHA;  
Q54PW5, DPH1_DICDI;  Q5AZJ7, DPH1_EMENI;  Q8SUZ5, DPH1_ENCCU;  
Q4IQ72, DPH1_GIBZE;  Q9BZG8, DPH1_HUMAN;  Q6CLC9, DPH1_KLULA;  
Q5NCQ5, DPH1_MOUSE;  A7SLX5, DPH1_NEMVE;  Q7SC98, DPH1_NEUCR;  
Q3T7C9, DPH1_PENVA;  O59713, DPH1_SCHPO;  Q4PA25, DPH1_USTMA;  
Q6GPQ5, DPH1_XENLA;  Q6C0S8, DPH1_YARLI;  P40487, DPH1_YEAST;  
Q57907, DPH2_METJA;  O58832, DPH2_PYRHO;  

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