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ENZYME

ENZYME entry: EC 2.5.1.108

Accepted Name
2-(3-amino-3-carboxypropyl)histidine synthase
Reaction catalysed
L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine = 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + H(+) + S-methyl-5'-thioadenosine
Comment(s)
  • Modifies a histidine residue of the translation elongation factor 2 (EF2) via a 3-amino-3-carboxypropyl radical.
  • The enzyme is present in archae and eukaryotes but not in eubacteria.
  • Part of diphthamide biosynthesis.
  • Formerly EC 2.5.1.n7.
Cross-references
BRENDA2.5.1.108
EC2PDB2.5.1.108
ExplorEnz2.5.1.108
PRIAM enzyme-specific profiles2.5.1.108
KEGG Ligand Database for Enzyme Nomenclature2.5.1.108
IUBMB Enzyme Nomenclature2.5.1.108
IntEnz2.5.1.108
MEDLINEFind literature relating to 2.5.1.108
MetaCyc2.5.1.108
Rhea expert-curated reactions2.5.1.108
UniProtKB/Swiss-Prot
Q4X0S7, DPH1_ASPFUQ3SYT1, DPH1_BOVINP49958, DPH1_CAEEL
Q59MG1, DPH1_CANALQ6FTG1, DPH1_CANGAQ5ZHX9, DPH1_CHICK
A0A8C2MDK8, DPH1_CRIGRP0CN19, DPH1_CRYNBP0CN18, DPH1_CRYNJ
Q567W6, DPH1_DANREQ6BPU5, DPH1_DEBHAQ54PW5, DPH1_DICDI
Q5AZJ7, DPH1_EMENIQ8SUZ5, DPH1_ENCCUQ75AZ9, DPH1_EREGS
Q4IQ72, DPH1_GIBZEQ9BZG8, DPH1_HUMANQ6CLC9, DPH1_KLULA
Q5NCQ5, DPH1_MOUSEA7SLX5, DPH1_NEMVEQ7SC98, DPH1_NEUCR
Q3T7C9, DPH1_PENVAO59713, DPH1_SCHPOQ4PA25, DPH1_USTMA
Q6GPQ5, DPH1_XENLAQ6C0S8, DPH1_YARLIP40487, DPH1_YEAST
Q57907, DPH2_METJAO58832, DPH2_PYRHO

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.5.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.5.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-