ENZYME entry: EC 2.5.1.108
| Accepted Name |
|---|
| 2-(3-amino-3-carboxypropyl)histidine synthase.
|
| Reaction catalysed |
|---|
| L-histidyl-[translation elongation factor 2] + S-adenosyl-L-methionine <=> 2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + H(+) + S-methyl-5'-thioadenosine |
| Comment(s) |
|---|
- Modifies a histidine residue of the translation elongation factor 2
(EF2) via a 3-amino-3-carboxypropyl radical.
- The enzyme is present in archae and eukaryotes but not in eubacteria.
- Part of diphthamide biosynthesis.
- Formerly EC 2.5.1.n7.
|
| Cross-references |
|---|
| BRENDA | 2.5.1.108 |
| EC2PDB | 2.5.1.108 |
| ExplorEnz | 2.5.1.108 |
| PRIAM enzyme-specific profiles | 2.5.1.108 |
| KEGG Ligand Database for Enzyme Nomenclature | 2.5.1.108 |
| IUBMB Enzyme Nomenclature | 2.5.1.108 |
| IntEnz | 2.5.1.108 |
| MEDLINE | Find literature relating to 2.5.1.108 |
| MetaCyc | 2.5.1.108 |
| Rhea expert-curated reactions | 2.5.1.108 |
| UniProtKB/Swiss-Prot |
| Q75AZ9, DPH1_ASHGO; | Q4X0S7, DPH1_ASPFU; | Q3SYT1, DPH1_BOVIN; |
| P49958, DPH1_CAEEL; | Q59MG1, DPH1_CANAL; | Q6FTG1, DPH1_CANGA; |
| Q5ZHX9, DPH1_CHICK; | A0A8C2MDK8, DPH1_CRIGR; | P0CN19, DPH1_CRYNB; |
| P0CN18, DPH1_CRYNJ; | Q567W6, DPH1_DANRE; | Q6BPU5, DPH1_DEBHA; |
| Q54PW5, DPH1_DICDI; | Q5AZJ7, DPH1_EMENI; | Q8SUZ5, DPH1_ENCCU; |
| Q4IQ72, DPH1_GIBZE; | Q9BZG8, DPH1_HUMAN; | Q6CLC9, DPH1_KLULA; |
| Q5NCQ5, DPH1_MOUSE; | A7SLX5, DPH1_NEMVE; | Q7SC98, DPH1_NEUCR; |
| Q3T7C9, DPH1_PENVA; | O59713, DPH1_SCHPO; | Q4PA25, DPH1_USTMA; |
| Q6GPQ5, DPH1_XENLA; | Q6C0S8, DPH1_YARLI; | P40487, DPH1_YEAST; |
| Q57907, DPH2_METJA; | O58832, DPH2_PYRHO; |
|
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