ENZYME entry: EC 2.5.1.114

PURL: https://purl.expasy.org/enzyme/EC/2.5.1.114

Accepted Name

tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase

Alternative Name(s)

tRNA-yW synthesizing enzyme-2

Reaction catalysed

4-demethylwyosine(37) in tRNA(Phe) + S-adenosyl-L-methionine = 4-demethyl-7-[(3S)-3-amino-3-carboxypropyl]wyosine(37) in tRNA(Phe) + S-methyl-5'-thioadenosine + H(+)

Comment(s)

The enzyme, which is found in all eukaryotes and in the majority of Euryarchaeota (but not in the Crenarchaeota), is involved in the hypermodification of the guanine nucleoside at position 37 of tRNA leading to formation of assorted wye bases.
This modification is essential for translational reading-frame maintenance.
The eukaryotic enzyme is involved in biosynthesis of the tricyclic base wybutosine, which is found only in tRNA(Phe).

Cross-references

BRENDA

2.5.1.114

EC2PDB

2.5.1.114

ExplorEnz

2.5.1.114

KEGG Ligand Database for Enzyme Nomenclature

2.5.1.114

IUBMB Enzyme Nomenclature

2.5.1.114

MEDLINE

Find literature relating to 2.5.1.114

MetaCyc

2.5.1.114

Rhea expert-curated reactions

2.5.1.114

UniProtKB/Swiss-Prot

Q8W4K1, TYW23_ARATH	Q8H4D4, TYW23_ORYSJ	Q58D65, TYW2_BOVIN
Q0P466, TYW2_DANRE	Q53H54, TYW2_HUMAN	Q4R3U8, TYW2_MACFA
Q58952, TYW2_METJA	Q8BG71, TYW2_MOUSE	O58523, TYW2_PYRHO
Q4V8B8, TYW2_RAT	Q09832, TYW2_SCHPO	Q04235, TYW2_YEAST

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.

All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.5.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.5.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-