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ENZYME entry: EC

Accepted Name
tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase.
Alternative Name(s)
tRNA-yW synthesizing enzyme-2.
Reaction catalysed
S-adenosyl-L-methionine + 4-demethylwyosine(37) in tRNA(Phe) <=> S-methyl-5'-thioadenosine + 7-((3S)-3-amino-3-carboxypropyl)-4-demethylwyosine(37) in tRNA(Phe)
  • The enzyme, which is found in all eukaryotes and in the majority of Euryarchaeota (but not in the Crenarchaeota), is involved in the hypermodification of the guanine nucleoside at position 37 of tRNA leading to formation of assorted wye bases.
  • This modification is essential for translational reading-frame maintenance.
  • The eukaryotic enzyme is involved in biosynthesis of the tricyclic base wybutosine, which is found only in tRNA(Phe).
PRIAM enzyme-specific profiles2.5.1.114
KEGG Ligand Database for Enzyme Nomenclature2.5.1.114
IUBMB Enzyme Nomenclature2.5.1.114
MEDLINEFind literature relating to
Rhea expert-curated reactions2.5.1.114
Q8W4K1, TYW23_ARATH;  Q8H4D4, TYW23_ORYSJ;  Q58D65, TYW2_BOVIN;  
Q0P466, TYW2_DANRE;  Q53H54, TYW2_HUMAN;  Q4R3U8, TYW2_MACFA;  
Q58952, TYW2_METJA;  Q8BG71, TYW2_MOUSE;  O58523, TYW2_PYRHO;  
Q4V8B8, TYW2_RAT;  Q09832, TYW2_SCHPO;  Q04235, TYW2_YEAST;  

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