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ENZYME entry: EC 2.5.1.120

Accepted Name
Aminodeoxyfutalosine synthase.
Alternative Name(s)
AFL synthase.
Aminofutalosine synthase.
Reaction catalysed
S-adenosyl-L-methionine + 3-((1-carboxyvinyl)oxy)benzoate + H(2)O <=> 6-amino-6-deoxyfutalosine + L-methionine + HCO(3)(-)
Comment(s)
  • This enzyme is a member of the 'AdoMet radical' (radical SAM) family.
  • S-adenosyl-L-methionine acts as both a radical generator and as the source of the transferred adenosyl group.
  • The enzyme, found in several bacterial species, is part of the futalosine pathway for menaquinone biosynthesis.
Cross-references
BRENDA2.5.1.120
EC2PDB2.5.1.120
ExplorEnz2.5.1.120
PRIAM enzyme-specific profiles2.5.1.120
KEGG Ligand Database for Enzyme Nomenclature2.5.1.120
IUBMB Enzyme Nomenclature2.5.1.120
IntEnz2.5.1.120
MEDLINEFind literature relating to 2.5.1.120
MetaCyc2.5.1.120
Rhea expert-curated reactions2.5.1.120
UniProtKB/Swiss-Prot
Q8CJT5, MQNE_STRCO;  Q5SK48, MQNE_THET8;  

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