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ENZYME entry: EC 2.5.1.126

Accepted Name
Norspermine synthase.
Alternative Name(s)
Long-chain polyamine synthase.
Reaction catalysed
S-adenosyl 3-(methylthio)propylamine + norspermidine <=> S-methyl-5'-thioadenosine + norspermine
Comment(s)
  • The enzyme, characterized from the thermophilic archaeon Pyrobaculum aerophilum, can also synthesize norspermidine from propane-1,3- diamine and thermospermine from spermidine (with lower activity).
  • The long-chain polyamines stabilize double-stranded DNA at high temperatures.
  • In contrast to EC 2.5.1.127, this enzyme does not accept norspermine as a substrate.
Cross-references
BRENDA2.5.1.126
EC2PDB2.5.1.126
ExplorEnz2.5.1.126
PRIAM enzyme-specific profiles2.5.1.126
KEGG Ligand Database for Enzyme Nomenclature2.5.1.126
IUBMB Enzyme Nomenclature2.5.1.126
IntEnz2.5.1.126
MEDLINEFind literature relating to 2.5.1.126
MetaCyc2.5.1.126
UniProtKB/Swiss-Prot
A2BIX4, SPEE1_HYPBU;  Q8ZXM4, SPEE_PYRAE;  Q9UXE4, SPEE_SACS2;  
Q5SK28, SPEE_THET8;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.5.1.-
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