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ENZYME

ENZYME entry: EC 2.5.1.126

PURL: https://purl.expasy.org/enzyme/EC/2.5.1.126
Accepted Name
norspermine synthase
Alternative Name(s)
long-chain polyamine synthase
Reaction catalysed
norspermidine + S-adenosyl 3-(methylsulfanyl)propylamine = norspermine + S-methyl-5'-thioadenosine + H(+)
Comment(s)
  • The enzyme, characterized from the thermophilic archaeon Pyrobaculum aerophilum, can also synthesize norspermidine from propane-1,3- diamine and thermospermine from spermidine (with lower activity).
  • The long-chain polyamines stabilize double-stranded DNA at high temperatures.
  • In contrast to EC 2.5.1.127, this enzyme does not accept norspermine as a substrate.
Cross-references
BRENDA2.5.1.126
EC2PDB2.5.1.126
ExplorEnz2.5.1.126
KEGG Ligand Database for Enzyme Nomenclature2.5.1.126
IUBMB Enzyme Nomenclature2.5.1.126
MEDLINEFind literature relating to 2.5.1.126
MetaCyc2.5.1.126
Rhea expert-curated reactions2.5.1.126
UniProtKB/Swiss-Prot
A2BIX4, SPEE1_HYPBUQ8ZXM4, SPEE_PYRAEQ9UXE4, SPEE_SACS2
Q5SK28, SPEE_THET8

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.5.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.5.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-