ID 2.5.1.128 DE N(4)-bis(aminopropyl)spermidine synthase. CA 2 S-adenosyl 3-(methylsulfanyl)propylamine + spermidine = 2 H(+) + N(4)- CA bis(aminopropyl)spermidine + 2 S-methyl-5'-thioadenosine. CC -!- The enzyme, characterized from the thermophilic archaeon Thermococcus CC kodakarensis, synthesizes the branched-chain polyamine N(4)- CC bis(aminopropyl)spermidine, which is required for cell growth at CC high-temperature. CC -!- When spermine is used as substrate, the enzyme forms N(4)- CC aminopropylspermine. DR Q58669, BPSA_METJA ; Q5JIZ3, BPSA_THEKO ; P25125, BPSA_THETH ; //