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ENZYME entry: EC 2.5.1.143

Accepted Name
Pyridinium-3,5-biscarboxylic acid mononucleotide synthase.
Alternative Name(s)
NaAD carboxylase/hydrolase.
Nicotinic acid adenine dinucleotide carboxylase/hydrolase.
P2CMN synthase.
Reaction catalysed
Deamido-NAD(+) + hydrogencarbonate <=> AMP + pyridinium-3,5-biscarboxylate mononucleotide
Comment(s)
  • This enzyme, found in the bacterium Lactobacillus plantarum, is involved in the biosynthesis of a nickel-pincer cofactor.
  • It carboxylates the pyridinium ring of deamido-NAD(+) and cleaves the phosphoanhydride bond to release AMP and generate pyridinium-3,5- biscarboxylic acid mononucleotide (P2CMN).
Cross-references
BRENDA2.5.1.143
EC2PDB2.5.1.143
ExplorEnz2.5.1.143
PRIAM enzyme-specific profiles2.5.1.143
KEGG Ligand Database for Enzyme Nomenclature2.5.1.143
IUBMB Enzyme Nomenclature2.5.1.143
IntEnz2.5.1.143
MEDLINEFind literature relating to 2.5.1.143
MetaCyc2.5.1.143
UniProtKB/Swiss-Prot
F9UST0, LARB_LACPL

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