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ENZYME

ENZYME entry: EC 2.5.1.143

PURL: https://purl.expasy.org/enzyme/EC/2.5.1.143
Accepted Name
pyridinium-3,5-biscarboxylic acid mononucleotide synthase
Alternative Name(s)
NaAD carboxylase/hydrolase
nicotinic acid adenine dinucleotide carboxylase/hydrolase
P2CMN synthase
Reaction catalysed
deamido-NAD(+) + hydrogencarbonate = pyridinium-3,5-dicarboxylate mononucleotide + AMP + 2 H(+)
Comment(s)
  • This enzyme, found in the bacterium Lactobacillus plantarum, is involved in the biosynthesis of a nickel-pincer cofactor.
  • It carboxylates the pyridinium ring of deamido-NAD(+) and cleaves the phosphoanhydride bond to release AMP and generate pyridinium-3,5- biscarboxylic acid mononucleotide (P2CMN).
Cross-references
BRENDA2.5.1.143
EC2PDB2.5.1.143
ExplorEnz2.5.1.143
KEGG Ligand Database for Enzyme Nomenclature2.5.1.143
IUBMB Enzyme Nomenclature2.5.1.143
MEDLINEFind literature relating to 2.5.1.143
MetaCyc2.5.1.143
Rhea expert-curated reactions2.5.1.143
UniProtKB/Swiss-Prot
F9UST0, LARB_LACPL

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