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ENZYME entry: EC 2.5.1.153

Accepted Name
Adenosine tuberculosinyltransferase.
Reaction catalysed
Tuberculosinyl diphosphate + adenosine <=> 1-tuberculosinyladenosine + diphosphate
Comment(s)
  • The enzyme, characterized from the bacterial pathogen Mycobacterium tuberculosis, produces 1-tuberculosinyladenosine, an unusual terpene nucleoside that acts as a phagolysosome disruptor by neutralizing the pH, resulting in swelling of the lysosome and obliteration of its multilamellar structure.
  • Formerly 3.1.7.8 and EC 3.1.7.9.
Cross-references
BRENDA2.5.1.153
EC2PDB2.5.1.153
ExplorEnz2.5.1.153
PRIAM enzyme-specific profiles2.5.1.153
KEGG Ligand Database for Enzyme Nomenclature2.5.1.153
IUBMB Enzyme Nomenclature2.5.1.153
IntEnz2.5.1.153
MEDLINEFind literature relating to 2.5.1.153
MetaCyc2.5.1.153
Rhea expert-curated reactions2.5.1.153
UniProtKB/Swiss-Prot
P9WJ60, TUBAT_MYCTO;  P9WJ61, TUBAT_MYCTU;  

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