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ENZYME

ENZYME entry: EC 2.5.1.153

PURL: https://purl.expasy.org/enzyme/EC/2.5.1.153
Accepted Name
adenosine tuberculosinyltransferase
Reaction catalysed
tuberculosinyl diphosphate + adenosine + H(+) = 1-tuberculosinyladenosine + diphosphate
Comment(s)
  • The enzyme, characterized from the bacterial pathogen Mycobacterium tuberculosis, produces 1-tuberculosinyladenosine, an unusual terpene nucleoside that acts as a phagolysosome disruptor by neutralizing the pH, resulting in swelling of the lysosome and obliteration of its multilamellar structure.
  • Formerly EC 3.1.7.8.
Cross-references
Rhea expert-curated reactions2.5.1.153
ExplorEnz2.5.1.153
IUBMB Enzyme Nomenclature2.5.1.153
UniProtKB/Swiss-Prot
P9WJ60, TUBAT_MYCTOP9WJ61, TUBAT_MYCTU
BRENDA2.5.1.153
MetaCyc2.5.1.153
KEGG Ligand Database for Enzyme Nomenclature2.5.1.153
EC2PDB2.5.1.153
MEDLINEFind literature relating to 2.5.1.153

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.5.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.5.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-